Different neuroanatomical correlates for temporal and spectral supra‐threshold auditory tasks and speech in noise recognition in older adults with hearing impairment

• Published in: The European journal of neuroscience 2023-03, Vol.57 (6), p.981-1002
• Main Authors: Neuschwander, Pia, Schmitt, Raffael, Jagoda, Laura, Kurthen, Ira, Giroud, Nathalie, Meyer, Martin
• Format: Article
• Language: English
• Subjects: Aged; ageing; Anatomy; Auditory Cortex - diagnostic imaging; Auditory Perception; Compression; Computed tomography; Frequency dependence; Hearing Loss; Hemispheric laterality; Humans; Morphometry; Noise; Noise pollution; Older people; Prefrontal cortex; pure‐tone hearing loss; Speech; speech in noise recognition; Speech Perception; Superior temporal sulcus; surface‐based morphometry; Temporal cortex
• ISSN: 0953-816X; 1460-9568
• DOI: 10.1111/ejn.15922

Varying degrees of pure‐tone hearing loss in older adults are differentially associated with cortical volume (CV) and thickness (CT) within and outside of the auditory pathway. This study addressed the question to what degree supra‐threshold auditory performance (i.e., temporal compression and frequency selectivity) as well as speech in noise (SiN) recognition are associated with neurostructural correlates in a sample of 59 healthy older adults with mild to moderate pure‐tone hearing loss. Using surface‐based morphometry on T1‐weighted MRI images, CT, CV, and surface area (CSA) of several regions‐of‐interest were obtained. The results showed distinct neurostructural patterns for the different tasks in terms of involved regions as well as morphometric parameters. While pure‐tone averages (PTAs) positively correlated with CT in a right hemisphere superior temporal sulcus and gyrus cluster, supra‐threshold auditory perception additionally extended significantly to CV and CT in left and right superior temporal clusters including Heschl's gyrus and sulcus, the planum polare and temporale. For SiN recognition, we found significant correlations with an auditory‐related CT cluster and furthermore with language‐related areas in the prefrontal cortex. Taken together, our results show that different auditory abilities are differently associated with cortical morphology in older adults with hearing impairment. Still, a common pattern is that greater PTAs and poorer supra‐threshold auditory performance as well as poorer SiN recognition are all related to cortical thinning and volume loss but not to changes in CSA. These results support the hypothesis that mostly CT undergoes alterations in the context of auditory decline, while CSA remains stable.