Surface Modification of lactose carrier particles using a fluid bed coater to improve fine particle fraction for dry powder inhalers

• Published in: Pharmaceutical development and technology 2023-02, Vol.28 (2), p.164-175
• Main Authors: Gong, Qin Qin, Tay, Justin Yong Soon, Veronica, Natalia, Xu, Jian, Heng, Paul Wan Sia, Zhang, Yong Ping, Liew, Celine Valeria
• Format: Article
• Language: English
• Subjects: Administration, Inhalation; Aerosols; Albuterol; Drug Carriers; Drug Delivery Systems - methods; Dry powder inhaler; Dry Powder Inhalers - methods; Excipients; fine particle fraction; fluid bed particle coating; Lactose; lactose carrier; Particle Size; Powders; Surface Properties; surface roughness
• ISSN: 1083-7450; 1097-9867
• DOI: 10.1080/10837450.2023.2171434

Surface roughness of carrier particles can impact dry powder inhaler (DPI) performance. There are opposing views on the effect of roughness on DPI performance. Hence, a systematic approach is needed to modify carrier surfaces and evaluate the impact on drug delivery. Carrier particle surfaces were modified by fluid bed coating with saturated lactose containing micronized lactose of different sizes (2, 5 and 8 μm) and coated to different levels (20, 40, 60 and 80%). Their drug delivery performance was assessed by the fine particle fraction (FPF). Roughness parameters, mean arithmetic roughness (R a ) and arithmetic mean height (S a ), of the carrier particles, were also evaluated using optical profilometry and scanning laser microscopy. Generally, particles of higher R a had higher FPF. Higher S a resulted in higher FPF only for particles with 60 and 80% coat levels. Reduced contact surface area between the drug particle and rougher carrier particle resulted in easier drug detachment during aerosolization. The 5 µm micronized lactose produced optimal carrier particles with respect to FPF and surface roughness. The study highlighted that with the ideal particles for surface roughening and coating level, surface roughening could be efficiently achieved by fluid bed coating for superior DPI performance.