Safety and efficacy of a novel robotic, fractional micro-coring device in a swine model

Laser resurfacing may be accompanied by unwanted side effects. The micro coring technology, designed to remove small skin columns, was developed to avoid the thermal injury associated with lasers. However, very limited data are available on its pre-clinical efficacy and safety. The novel robotic, fr...

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Bibliographic Details
Published in:Journal of Toxicologic Pathology 2023, Vol.36(1), pp.11-19
Main Authors: Ramot, Yuval, Vazana, Udi, Cacical, Orna, Nyska, Abraham
Format: Article
Language:English
Subjects:
Ablation
Animal models
Coring
dermatology
Dermis
Edema
Effectiveness
Epidermis
Erythema
Healing
Injury prevention
Lasers
micro-coring
plastic surgery
rejuvenation
Resurfacing
Safety
Side effects
Skin
Swine
Thermal injury
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Summary:Laser resurfacing may be accompanied by unwanted side effects. The micro coring technology, designed to remove small skin columns, was developed to avoid the thermal injury associated with lasers. However, very limited data are available on its pre-clinical efficacy and safety. The novel robotic, fractional micro-coring device, AimeTM, was tested on four pigs, each treated in 12 sites, at 6 time-points, over the course of 28 days. Macroscopic and microscopic evaluation was performed at each of the 6 time-points during the 28-day follow-up. Macroscopically, treatment resulted in erythema and mild edema that quickly resolved. Microscopically, there was progressive re-coverage of the tested sites with complete, well differentiated, newly formed epidermis, associated with efficient elimination of the underlying excised dermis, which was replaced by maturing fibroplasia. Some of the sites demonstrated complete healing already after 7 days. No significant adverse events were noted with the use of the device. The use of the micro-coring device AimeTM in a porcine model for skin fractional micro-excision and resurfacing was effective and safe. The comprehensive gradual healing process shown in this study with detailed histopathological images can also serve as a basis for future pre-clinical studies of fractional ablative devices.
ISSN:0914-9198
1881-915X
1347-7404
DOI:10.1293/tox.2022-0079