Biological effects of extracorporeal shockwave therapy in tendons: A systematic review

Extracorporeal shockwave therapy was initially used for kidney stone disintegration and its application was then extended to calcific tendinitis. The therapeutic field expanded and included numerous types of tendinopathies, from shoulder to plantar fascia. The clinical benefits were documented in tr...

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Bibliographic Details
Published in:Biomedical reports 2023-02, Vol.18 (2), p.15-15, Article 15
Main Authors: Poenaru, Daniela, Sandulescu, Miruna Ioana, Cinteza, Delia
Format: Article
Language:English
Subjects:
Analysis
Animal models
Biological effects
Biomechanics
Calculi
Cell culture
Clinical trials
Collagen
Disintegration
Extracellular matrix
Fascia
Health aspects
Kidney stones
Kidneys
Mechanical properties
Metalloproteinase
Nephrolithiasis
Plantar tissues
Tendons
Vascularization
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Summary:Extracorporeal shockwave therapy was initially used for kidney stone disintegration and its application was then extended to calcific tendinitis. The therapeutic field expanded and included numerous types of tendinopathies, from shoulder to plantar fascia. The clinical benefits were documented in trials and the effects and mechanisms were studied on models including animal and human tendons. The present systematic review outlines a large spectrum of biological effects. First, an optimal dose is adapted for each species and each tendon; exceeding the optimal dose may lead to structural injury. Furthermore, the biological effects may be grouped into neovascularization induction, cellularity and extracellular matrix changes, metalloprotease and cytokine modulation, as well as lubricin production. As a result, the remodeled tendon displays improved biomechanical properties to resist stress.
ISSN:2049-9434
2049-9442
DOI:10.3892/br.2022.1597