Syringic acid ameliorates ischemia/reperfusion-induced testicular injury in rats via suppressing of HMGB1/NF-κB axis and endoplasmic reticulum stress

Purpose To investigate the possible protective role of syringic acid on torsion/detorsion-induced testicular injury using biochemical and histopathological approaches for the first time. Methods A total of 24 rats were divided into 4 groups: sham control, torsion/detorsion, torsion/detorsion + syrin...

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Published in:European journal of trauma and emergency surgery (Munich : 2007) 2023-06, Vol.49 (3), p.1595-1602
Main Authors: Demir, Elif Ayazoglu, Demir, Selim, Kazaz, Ilke Onur, Kucuk, Hatice, Alemdar, Nihal Turkmen, Gecici, Omer Faruk, Mentese, Ahmet, Aliyazicioglu, Yuksel
Format: Article
Language:English
Subjects:
Acids
Animals
Apoptosis
Critical Care Medicine
Emergency medical care
Emergency Medicine
Endoplasmic reticulum
Endoplasmic Reticulum Stress
HMGB1 Protein - metabolism
Intensive
Ischemia
Male
Medicine
Medicine & Public Health
NF-kappa B - metabolism
Original Article
Oxidative stress
Proteins
Rats
Reperfusion
Sports Medicine
Surgery
Surgical Orthopedics
Testis - metabolism
Testis - pathology
Traumatic Surgery
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Summary:Purpose To investigate the possible protective role of syringic acid on torsion/detorsion-induced testicular injury using biochemical and histopathological approaches for the first time. Methods A total of 24 rats were divided into 4 groups: sham control, torsion/detorsion, torsion/detorsion + syringic acid (50 mg/kg and 100 mg/kg). Tissue malondialdehyde, total oxidant status and total antioxidant status levels were determined using colorimetric methods. Tissue 8-hydroxy-2′-deoxyguanosine, superoxide dismutase, catalase, high mobility group box 1, nuclear factor kappa B protein 65, tumor necrosis factor-alpha, interleukin-6, myeloperoxidase, 78-kDa glucose-regulated protein, activating transcription factor-6, C/EBP homologous protein and caspase-3 levels were determined using commercial enzyme-linked immunosorbent assay kits. Johnsen’s testicle scoring system was used for histological evaluation. Results Compared with the control group, the levels of oxidative stress, inflammation, endoplasmic reticulum stress and apoptosis were significantly increased in the torsion/detorsion group ( p  
ISSN:1863-9933
1863-9941
DOI:10.1007/s00068-023-02227-7