Cerebral regional tissue Oxygen Saturation to Guide Oxygen Delivery in preterm neonates during immediate transition after birth (COSGOD III): multicentre randomised phase 3 clinical trial

AbstractObjectiveTo investigate whether monitoring of cerebral tissue oxygen saturation using near infrared spectroscopy in addition to routine monitoring combined with defined treatment guidelines during immediate transition and resuscitation increases survival without cerebral injury of premature...

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Published in:BMJ (Online) 2023-01, Vol.380, p.e072313
Main Authors: Pichler, Gerhard, Goeral, Katharina, Hammerl, Marlene, Perme, Tina, Dempsey, Eugene M, Springer, Laila, Lista, Gianluca, Szczapa, Tomasz, Fuchs, Hans, Karpinski, Lukasz, Bua, Jenny, Avian, Alexander, Law, Brenda, Urlesberger, Berndt, Buchmayer, Julia, Kiechl-Kohlendorfer, Ursula, Kornhauser-Cerar, Lilijana, Schwarz, Christoph E, Gründler, Kerstin, Stucchi, Ilaria, Schwaberger, Bernhard, Klebermass-Schrehof, Katrin, Schmölzer, Georg M, Wolfsberger, Christina, Baik-Schneditz, Nariae, Bruckner, Marlies, Binder-Heschl, Corinna, Pfurtscheller, Daniel, Martensen, Johann, Höller, Nina, Ziehenberger, Evelyn, Berger, Angelika, Baumgartner, Sigrid, Grill, Agnes, Mayr, Michaela, Rittenschober-Boehm, Judith, Schneider, Michael, Schreiner, Christina, Griesmaier, Elke, Neubauer, Vera, Wöckinger, Peter, Posod, Anna, Marolt, Anja, Dimnik, Ana, Lubej Kurtovič, Vlasta, Aisling, Garvey, Panaviene, Jurate, Healy, David, Ahmed, Nahla, Herlihy, Ita, Franz, Axel, Castoldi, Francesca, Cavigioli, Francesco, Kozłowska, Zuzanna, Minta, Marcin, Owsiańska, Zuzanna, Kahtan, Sonia, Neumann-Klimasińska, Natalia, Wróbel, Karolina, Kubiaczyk, Agata, Kosik, Katarzyna, Olek, Katarzyna, Bugiera, Michalina, Porwolik, Julita, Basiukajć, Agnieszka, Czapla, Elzbieta, Łukaszuk, Wojciech, Gryczka, Katarzyna, Naskręcka, Dobrochna, Mazela, Jan, Szymankiewicz-Bręborowicz, Marta, Klotz, Daniel, Baumgartner, Jana, Bembich, Stefano, Travan, Laura, Cheung, Po-Yin
Format: Article
Language:English
Subjects:
Birth
Brain - diagnostic imaging
Brain Injuries
Clinical trials
Electrocardiography
Female
Gestational Age
Heart rate
Hemorrhage
Humans
Infant
Infant, Newborn
Infant, Premature
Infrared spectroscopy
Intensive care
Intensive care units
Intervention
Mortality
Multiple births
Neonates
Newborn babies
Oxygen
Oxygen Saturation
Periventricular leukomalacia
Pregnancy
Premature babies
Premature birth
Pulse oximetry
Sensors
Spectrum analysis
Statistical analysis
Survival
Ultrasonic imaging
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Summary:AbstractObjectiveTo investigate whether monitoring of cerebral tissue oxygen saturation using near infrared spectroscopy in addition to routine monitoring combined with defined treatment guidelines during immediate transition and resuscitation increases survival without cerebral injury of premature infants compared with standard care alone.DesignMulticentre, multinational, randomised controlled phase 3 trial.Setting11 tertiary neonatal intensive care units in six countries in Europe and in Canada.Participants1121 pregnant women (
ISSN:1756-1833
1756-1833
DOI:10.1136/bmj-2022-072313