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Randomized controlled trial of a novel lifestyle intervention used with or without meal replacements in work sites
Objective Lifestyle interventions have had limited effectiveness in work sites when evaluated in randomized trials. This study assessed the effectiveness of a novel lifestyle intervention for weight loss (Healthy Weight for Living [HWL]) implemented with or without meal replacements (MR) in work sit...
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| Published in: | Obesity (Silver Spring, Md.) Md.), 2023-02, Vol.31 (2), p.374-389 |
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| Main Authors: | , , , , , , , , , , |
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| container_end_page | 389 |
| container_issue | 2 |
| container_start_page | 374 |
| container_title | Obesity (Silver Spring, Md.) |
| container_volume | 31 |
| creator | Das, Sai Krupa Silver, Rachel E. Vail, Taylor A. Chin, Meghan K. Blanchard, Caroline M. Dickinson, Stephanie L. Chen, Xiwei Ceglia, Lisa Saltzman, Edward Allison, David B. Roberts, Susan B. |
| description | Objective
Lifestyle interventions have had limited effectiveness in work sites when evaluated in randomized trials. This study assessed the effectiveness of a novel lifestyle intervention for weight loss (Healthy Weight for Living [HWL]) implemented with or without meal replacements (MR) in work sites. HWL used a new behavioral approach emphasizing reducing hunger and building healthy food preferences, and, unlike traditional lifestyle interventions, it did not require calorie counting.
Methods
Twelve work sites were randomized to an 18‐month intervention (n = 8; randomization within work sites to HWL, HWL + MR) or 6‐month wait‐listed control (n = 4). Participants were employees with overweight or obesity (N = 335; age = 48 [SD 10] years; BMI = 33 [6] kg/m2; 83% female). HWL was group‐delivered in person or by videoconference. The primary outcome was 6‐month weight change; secondary outcomes included weight and cardiometabolic risk factors measured at 6, 12, and 18 months in intervention groups.
Results
Mean 6‐month weight change was −8.8% (95% CI: −11.2% to −6.4%) for enrollees in HWL and −8.0% (−10.4% to −5.5%) for HWL + MR (p |
| doi_str_mv | 10.1002/oby.23636 |
| format | article |
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Lifestyle interventions have had limited effectiveness in work sites when evaluated in randomized trials. This study assessed the effectiveness of a novel lifestyle intervention for weight loss (Healthy Weight for Living [HWL]) implemented with or without meal replacements (MR) in work sites. HWL used a new behavioral approach emphasizing reducing hunger and building healthy food preferences, and, unlike traditional lifestyle interventions, it did not require calorie counting.
Methods
Twelve work sites were randomized to an 18‐month intervention (n = 8; randomization within work sites to HWL, HWL + MR) or 6‐month wait‐listed control (n = 4). Participants were employees with overweight or obesity (N = 335; age = 48 [SD 10] years; BMI = 33 [6] kg/m2; 83% female). HWL was group‐delivered in person or by videoconference. The primary outcome was 6‐month weight change; secondary outcomes included weight and cardiometabolic risk factors measured at 6, 12, and 18 months in intervention groups.
Results
Mean 6‐month weight change was −8.8% (95% CI: −11.2% to −6.4%) for enrollees in HWL and −8.0% (−10.4% to −5.5%) for HWL + MR (p < 0.001 for both groups vs. controls), with no difference between interventions (p = 0.40). Clinically meaningful weight loss (≥5%) was maintained at 18 months in both groups (p < 0.001).
Conclusions
A new lifestyle intervention approach, deliverable by videoconference with or without MR, supported clinically impactful weight loss in employees.</description><identifier>ISSN: 1930-7381</identifier><identifier>EISSN: 1930-739X</identifier><identifier>DOI: 10.1002/oby.23636</identifier><identifier>PMID: 36695057</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Body mass index ; Clinical trials ; Consent ; Employees ; Female ; Food ; Humans ; Hypotheses ; Intervention ; Life Style ; Lifestyles ; Male ; Meals ; Middle Aged ; Obesity - complications ; Obesity - therapy ; Overweight - complications ; Overweight - therapy ; Weight control ; Weight Loss</subject><ispartof>Obesity (Silver Spring, Md.), 2023-02, Vol.31 (2), p.374-389</ispartof><rights>2023 The Obesity Society.</rights><rights>Copyright Blackwell Publishing Ltd. Feb 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3886-9682a8c35e7454f96fbd88f52487d4da195baefc88de823d6dbd3aa1b75407a23</citedby><cites>FETCH-LOGICAL-c3886-9682a8c35e7454f96fbd88f52487d4da195baefc88de823d6dbd3aa1b75407a23</cites><orcidid>0000-0003-1608-7561 ; 0000-0002-2998-4467 ; 0000-0003-0788-0461 ; 0000-0003-1320-8460</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36695057$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Das, Sai Krupa</creatorcontrib><creatorcontrib>Silver, Rachel E.</creatorcontrib><creatorcontrib>Vail, Taylor A.</creatorcontrib><creatorcontrib>Chin, Meghan K.</creatorcontrib><creatorcontrib>Blanchard, Caroline M.</creatorcontrib><creatorcontrib>Dickinson, Stephanie L.</creatorcontrib><creatorcontrib>Chen, Xiwei</creatorcontrib><creatorcontrib>Ceglia, Lisa</creatorcontrib><creatorcontrib>Saltzman, Edward</creatorcontrib><creatorcontrib>Allison, David B.</creatorcontrib><creatorcontrib>Roberts, Susan B.</creatorcontrib><title>Randomized controlled trial of a novel lifestyle intervention used with or without meal replacements in work sites</title><title>Obesity (Silver Spring, Md.)</title><addtitle>Obesity (Silver Spring)</addtitle><description>Objective
Lifestyle interventions have had limited effectiveness in work sites when evaluated in randomized trials. This study assessed the effectiveness of a novel lifestyle intervention for weight loss (Healthy Weight for Living [HWL]) implemented with or without meal replacements (MR) in work sites. HWL used a new behavioral approach emphasizing reducing hunger and building healthy food preferences, and, unlike traditional lifestyle interventions, it did not require calorie counting.
Methods
Twelve work sites were randomized to an 18‐month intervention (n = 8; randomization within work sites to HWL, HWL + MR) or 6‐month wait‐listed control (n = 4). Participants were employees with overweight or obesity (N = 335; age = 48 [SD 10] years; BMI = 33 [6] kg/m2; 83% female). HWL was group‐delivered in person or by videoconference. The primary outcome was 6‐month weight change; secondary outcomes included weight and cardiometabolic risk factors measured at 6, 12, and 18 months in intervention groups.
Results
Mean 6‐month weight change was −8.8% (95% CI: −11.2% to −6.4%) for enrollees in HWL and −8.0% (−10.4% to −5.5%) for HWL + MR (p < 0.001 for both groups vs. controls), with no difference between interventions (p = 0.40). Clinically meaningful weight loss (≥5%) was maintained at 18 months in both groups (p < 0.001).
Conclusions
A new lifestyle intervention approach, deliverable by videoconference with or without MR, supported clinically impactful weight loss in employees.</description><subject>Body mass index</subject><subject>Clinical trials</subject><subject>Consent</subject><subject>Employees</subject><subject>Female</subject><subject>Food</subject><subject>Humans</subject><subject>Hypotheses</subject><subject>Intervention</subject><subject>Life Style</subject><subject>Lifestyles</subject><subject>Male</subject><subject>Meals</subject><subject>Middle Aged</subject><subject>Obesity - complications</subject><subject>Obesity - therapy</subject><subject>Overweight - complications</subject><subject>Overweight - therapy</subject><subject>Weight control</subject><subject>Weight Loss</subject><issn>1930-7381</issn><issn>1930-739X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNp10UtLxDAQB_Agiu-DX0ACXvSwmkeTpkcVXyAIoqCnkDZTjKbNmrQu66c3uupB8DRz-M2fYQahHUoOKSHsKNTzQ8Yll0tonVacTEpePSz_9oquoY2UngkpJBF0Fa1xKStBRLmO4q3pbejcO1jchH6IwfvcDtEZj0OLDe7DG3jsXQtpmHvArh8gvkE_uNDjMWU8c8MTDvGrhnHAHeTZCFNvGugyTHkGz0J8wckNkLbQSmt8gu3vuonuz8_uTi8n1zcXV6fH15OGKyUnlVTMqIYLKAtRtJVsa6tUK1ihSltYQytRG2gbpSwoxq20teXG0LoUBSkN45tof5E7jeF1zNvrzqUGvDc9hDFpVuYjVFRJmuneH_ocxtjn7TRThAlBiFRZHSxUE0NKEVo9ja4zca4p0Z-P0PkR-usR2e5-J451B_ZX_lw-g6MFmDkP8_-T9M3J4yLyA7nOlBc</recordid><startdate>202302</startdate><enddate>202302</enddate><creator>Das, Sai Krupa</creator><creator>Silver, Rachel E.</creator><creator>Vail, Taylor A.</creator><creator>Chin, Meghan K.</creator><creator>Blanchard, Caroline M.</creator><creator>Dickinson, Stephanie L.</creator><creator>Chen, Xiwei</creator><creator>Ceglia, Lisa</creator><creator>Saltzman, Edward</creator><creator>Allison, David B.</creator><creator>Roberts, Susan B.</creator><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-1608-7561</orcidid><orcidid>https://orcid.org/0000-0002-2998-4467</orcidid><orcidid>https://orcid.org/0000-0003-0788-0461</orcidid><orcidid>https://orcid.org/0000-0003-1320-8460</orcidid></search><sort><creationdate>202302</creationdate><title>Randomized controlled trial of a novel lifestyle intervention used with or without meal replacements in work sites</title><author>Das, Sai Krupa ; Silver, Rachel E. ; Vail, Taylor A. ; Chin, Meghan K. ; Blanchard, Caroline M. ; Dickinson, Stephanie L. ; Chen, Xiwei ; Ceglia, Lisa ; Saltzman, Edward ; Allison, David B. ; Roberts, Susan B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3886-9682a8c35e7454f96fbd88f52487d4da195baefc88de823d6dbd3aa1b75407a23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Body mass index</topic><topic>Clinical trials</topic><topic>Consent</topic><topic>Employees</topic><topic>Female</topic><topic>Food</topic><topic>Humans</topic><topic>Hypotheses</topic><topic>Intervention</topic><topic>Life Style</topic><topic>Lifestyles</topic><topic>Male</topic><topic>Meals</topic><topic>Middle Aged</topic><topic>Obesity - complications</topic><topic>Obesity - therapy</topic><topic>Overweight - complications</topic><topic>Overweight - therapy</topic><topic>Weight control</topic><topic>Weight Loss</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Das, Sai Krupa</creatorcontrib><creatorcontrib>Silver, Rachel E.</creatorcontrib><creatorcontrib>Vail, Taylor A.</creatorcontrib><creatorcontrib>Chin, Meghan K.</creatorcontrib><creatorcontrib>Blanchard, Caroline M.</creatorcontrib><creatorcontrib>Dickinson, Stephanie L.</creatorcontrib><creatorcontrib>Chen, Xiwei</creatorcontrib><creatorcontrib>Ceglia, Lisa</creatorcontrib><creatorcontrib>Saltzman, Edward</creatorcontrib><creatorcontrib>Allison, David B.</creatorcontrib><creatorcontrib>Roberts, Susan B.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Obesity (Silver Spring, Md.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Das, Sai Krupa</au><au>Silver, Rachel E.</au><au>Vail, Taylor A.</au><au>Chin, Meghan K.</au><au>Blanchard, Caroline M.</au><au>Dickinson, Stephanie L.</au><au>Chen, Xiwei</au><au>Ceglia, Lisa</au><au>Saltzman, Edward</au><au>Allison, David B.</au><au>Roberts, Susan B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Randomized controlled trial of a novel lifestyle intervention used with or without meal replacements in work sites</atitle><jtitle>Obesity (Silver Spring, Md.)</jtitle><addtitle>Obesity (Silver Spring)</addtitle><date>2023-02</date><risdate>2023</risdate><volume>31</volume><issue>2</issue><spage>374</spage><epage>389</epage><pages>374-389</pages><issn>1930-7381</issn><eissn>1930-739X</eissn><abstract>Objective
Lifestyle interventions have had limited effectiveness in work sites when evaluated in randomized trials. This study assessed the effectiveness of a novel lifestyle intervention for weight loss (Healthy Weight for Living [HWL]) implemented with or without meal replacements (MR) in work sites. HWL used a new behavioral approach emphasizing reducing hunger and building healthy food preferences, and, unlike traditional lifestyle interventions, it did not require calorie counting.
Methods
Twelve work sites were randomized to an 18‐month intervention (n = 8; randomization within work sites to HWL, HWL + MR) or 6‐month wait‐listed control (n = 4). Participants were employees with overweight or obesity (N = 335; age = 48 [SD 10] years; BMI = 33 [6] kg/m2; 83% female). HWL was group‐delivered in person or by videoconference. The primary outcome was 6‐month weight change; secondary outcomes included weight and cardiometabolic risk factors measured at 6, 12, and 18 months in intervention groups.
Results
Mean 6‐month weight change was −8.8% (95% CI: −11.2% to −6.4%) for enrollees in HWL and −8.0% (−10.4% to −5.5%) for HWL + MR (p < 0.001 for both groups vs. controls), with no difference between interventions (p = 0.40). Clinically meaningful weight loss (≥5%) was maintained at 18 months in both groups (p < 0.001).
Conclusions
A new lifestyle intervention approach, deliverable by videoconference with or without MR, supported clinically impactful weight loss in employees.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>36695057</pmid><doi>10.1002/oby.23636</doi><tpages>16</tpages><orcidid>https://orcid.org/0000-0003-1608-7561</orcidid><orcidid>https://orcid.org/0000-0002-2998-4467</orcidid><orcidid>https://orcid.org/0000-0003-0788-0461</orcidid><orcidid>https://orcid.org/0000-0003-1320-8460</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1930-7381 |
| ispartof | Obesity (Silver Spring, Md.), 2023-02, Vol.31 (2), p.374-389 |
| issn | 1930-7381 1930-739X |
| language | eng |
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| source | Wiley:Jisc Collections:Wiley Read and Publish Open Access 2024-2025 (reading list) |
| subjects | Body mass index Clinical trials Consent Employees Female Food Humans Hypotheses Intervention Life Style Lifestyles Male Meals Middle Aged Obesity - complications Obesity - therapy Overweight - complications Overweight - therapy Weight control Weight Loss |
| title | Randomized controlled trial of a novel lifestyle intervention used with or without meal replacements in work sites |
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