Effect of menopause and age on vascular impairment

•Cardiovascular disease in aging women is a growing problem.•89 women initiated the study and 74 of them participated in the 10-year follow-up (from 46 till 56 years of age).•We found early changes in cardiovascular risk factors and sleep-disordered breathing.•Early signs of sleep-disordered breathi...

Full description

Saved in:
Bibliographic Details
Published in:Maturitas 2023-03, Vol.169, p.46-52
Main Authors: Aittokallio, Jenni, Saaresranta, Tarja, Riskumäki, Markus, Hautajärvi, Tiina, Vahlberg, Tero, Polo, Olli, Heinonen, Olli, Raitakari, Olli, Kalleinen, Nea
Format: Article
Language:English
Subjects:
Aging
Brachial Artery - diagnostic imaging
Brachial Artery - physiology
Cardiovascular Diseases - etiology
Cardiovascular risk factors
Endothelium, Vascular - physiology
Female
Hormonal therapy
Humans
Hypoxia - complications
Menopause
Nitroglycerin - pharmacology
Obesity - complications
Vascular impairment
Vasodilation
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:•Cardiovascular disease in aging women is a growing problem.•89 women initiated the study and 74 of them participated in the 10-year follow-up (from 46 till 56 years of age).•We found early changes in cardiovascular risk factors and sleep-disordered breathing.•Early signs of sleep-disordered breathing, obesity and impaired glucose control in middle age contribute to vascular decline in women even after 10 years. The prevalence of cardiovascular diseases increases in women after menopause. The aim of the study was to determine the impact of conventional cardiovascular risk factors such as age, blood pressure, smoking, cholesterol, obesity, and glucose balance, but also menopausal state and sleep-disordered breathing on vascular impairment during menopausal transition. 89 women initiated the study and 74 of them participated in the 10-year follow-up. Cardiovascular disease risk factor assessments, ultrasound measurements of brachial artery function, including nitroglycerin-mediated vasodilatation and flow-mediated endothelium-dependent vasodilation, and sleep studies were repeated at baseline and at 5-year and 10-year follow-ups. Over the study period, all the cardiovascular disease risk estimates increased. Both flow-mediated endothelium-dependent vasodilatation (decline 55 %) and nitroglycerin-mediated vasodilatation (decline 18 %) worsened over the 10 years (p 
ISSN:0378-5122
1873-4111
DOI:10.1016/j.maturitas.2023.01.006