Research progress of metformin in the treatment of liver fibrosis

•Metformin can alleviate the progression of liver fibrosis.•Metformin plays an important role in liver fibrosis through multiple cells including hepatic stellate cells, kupffer cells and hepatocytes.•The epidemiologic findings of metformin in the prevention and treatment of liver fibrosis are highly...

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Published in:International immunopharmacology 2023-03, Vol.116, p.109738-109738, Article 109738
Main Authors: Zhang, Anqi, Qian, Fangyi, Li, Yangyang, Li, Bowen, Yang, Furong, Hu, Chengmu, Sun, Wuyi, Huang, Yan
Format: Article
Language:English
Subjects:
Fibrosis
HSC
Humans
Hypoglycemic Agents - therapeutic use
Liver - pathology
Liver Cirrhosis - metabolism
Liver fibrosis
Metformin
Metformin - therapeutic use
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Summary:•Metformin can alleviate the progression of liver fibrosis.•Metformin plays an important role in liver fibrosis through multiple cells including hepatic stellate cells, kupffer cells and hepatocytes.•The epidemiologic findings of metformin in the prevention and treatment of liver fibrosis are highly instructive. Liver fibrosis is a disease with significant morbidity and mortality. It is a chronic pathological process characterized by an imbalance of extracellular matrix production and degradation in liver tissue. Metformin is a type of hypoglycemic biguanide drug, which can be used in the treatment of liver fibrosis, but its anti-fibrotic effect and mechanism of action are unclear. The purpose of this article is to review the research progress of metformin in the treatment of liver fibrosis and to provide a theoretical basis for its application in the treatment of liver fibrosis.
ISSN:1567-5769
1878-1705
DOI:10.1016/j.intimp.2023.109738