Retrospective Window of Interest Annotation Provides New Insights Into Functional Channels in Ventricular Tachycardia Substrate

• Published in: JACC. Clinical electrophysiology 2023-01, Vol.9 (1), p.1-16
• Main Authors: Hawson, Joshua, Al-kaisey, Ahmed, Anderson, Robert D., Chieng, David, Segan, Louise, Watts, Troy, Campbell, Timothy, Morton, Joseph, McLellan, Alexander, Sparks, Paul, Lee, Adam, Gerstenfeld, Edward P., Hsia, Henry H., Voskoboinik, Aleksander, Prabhu, Sandeep, Pathik, Bhupesh, Kumar, Saurabh, Kistler, Peter, Kalman, Jonathan, Lee, Geoffrey
• Format: Article
• Language: English
• Subjects: Arrhythmias, Cardiac; Catheter Ablation - methods; Electrophysiologic Techniques, Cardiac - methods; functional substrate mapping; Heart Ventricles; Humans; ILAM; Lipopolysaccharides; Prospective Studies; Retrospective Studies; Tachycardia, Ventricular - surgery; ventricular arrhythmias; ventricular tachycardia
• ISSN: 2405-500X; 2405-5018
• DOI: 10.1016/j.jacep.2022.10.025

Accurate annotation of local activation time is crucial in the functional assessment of ventricular tachycardia (VT) substrate. A major limitation of modern mapping systems is the standard prospective window of interest (sWOI) is limited to 490 to 500 milliseconds, preventing annotation of very late potentials (LPs). A novel retrospective window of interest (rWOI), which allows annotation of all diastolic potentials, was used to assess the functional VT substrate. This study sought to investigate the utility of a novel rWOI, which allows accurate visualization and annotation of all LPs during VT substrate mapping. Patients with high-density VT substrate maps and a defined isthmus were included. All electrograms were manually annotated to latest activation using a novel rWOI. Reannotated substrate maps were correlated to critical sites, with areas of late activation examined. Propagation patterns were examined to assess the functional aspects of the VT substrate. Forty-eight cases were identified with 1,820 ± 826 points per map. Using the novel rWOI, 31 maps (65%) demonstrated LPs beyond the sWOI limit. Two distinct patterns of channel activation were seen during substrate mapping: 1) functional block with unidirectional conduction into the channel (76%); and 2) wave front collision within the channel (24%). In addition, a novel marker termed the zone of early and late crowding was studied in the rWOI substrate maps and found to have a higher positive predictive value (85%) than traditional deceleration zones (69%) for detecting critical sites of re-entry. The standard WOI of contemporary mapping systems is arbitrarily limited and results in important very late potentials being excluded from annotation. Future versions of electroanatomical mapping systems should provide longer WOIs for accurate local activation time annotation. [Display omitted]