Andrographolide-Soya-L-α-Phosphatidyl Choline Complex Augmented Solubility and Drug Delivery in Leishmania donovani, a Causative Agent for Cutaneous and Visceral Leishmaniasis

The utility of andrographolide (AN) in visceral leishmaniasis (VL) and cutaneous leishmaniasis (CL) is limited owing to poor solubility, hindered permeation, and unstable structure under physiological conditions. The present study mainly focuses on synthesizing of andrographolide-Soya-L-α-phosphatid...

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Published in:AAPS PharmSciTech 2023-01, Vol.24 (1), p.46-46, Article 46
Main Authors: Pingle, Purva, Mourya, Atul, Namdeo, Madhulika, Babu, Katta Chanti, Veerabomma, Harithasree, Maurya, Radheshyam, Singh, Pankaj Kumar, Mehra, Neelesh Kumar, Srivastava, Saurabh, Madan, Jitender
Format: Article
Language:English
Subjects:
Biochemistry
Biomedical and Life Sciences
Biomedicine
Biotechnology
Humans
Lecithins - metabolism
Leishmania donovani - metabolism
Leishmaniasis, Visceral - drug therapy
Leishmaniasis, Visceral - parasitology
Pharmacology/Toxicology
Pharmacy
Research Article
Solubility
Spectroscopy, Fourier Transform Infrared
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Summary:The utility of andrographolide (AN) in visceral leishmaniasis (VL) and cutaneous leishmaniasis (CL) is limited owing to poor solubility, hindered permeation, and unstable structure under physiological conditions. The present study mainly focuses on synthesizing of andrographolide-Soya-L-α-phosphatidyl choline (ANSPC) complex in ethanol and its characterization using various spectral and analytical techniques. Results from FT-IR, 1 H NMR, ROSEY, and in silico docking techniques suggest ANSPC complex formation due to inter-molecular interaction between the hydrophilic head of SPC and hydroxyl group of AN present at 24th position. ANSPC complex demonstrated the solubility of 113.93 ± 6.66 μg/mL significantly ( P  
ISSN:1530-9932
1530-9932
DOI:10.1208/s12249-023-02507-w