Impact of very early introduction of everolimus on liver regeneration after partial liver transplantation in rats

Background/Purpose This experimental study in rats aimed to investigate the impact of very early introduction (within 3 h) of everolimus (EVR) + reduced‐tacrolimus (TAC) after partial liver transplantation (LT) on liver regeneration, rejection, and survival. Methods Based on appropriate dose of EVR ...

Full description

Saved in:
Bibliographic Details
Published in:Journal of hepato-biliary-pancreatic sciences 2023-07, Vol.30 (7), p.882-892
Main Authors: Hirata, Masaaki, Yagi, Shintaro, Ito, Takashi, Masano, Yuki, Miyachi, Yosuke, Yao, Siyuan, Sonoda, Mari, Masuda, Satohiro, Haga, Hironori, Hatano, Etsuro
Format: Article
Language:English
Subjects:
immunosuppressive regimen
Infections
Liver
Liver transplants
mTOR inhibitor
partial liver graft
postoperative complications
rejection
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background/Purpose This experimental study in rats aimed to investigate the impact of very early introduction (within 3 h) of everolimus (EVR) + reduced‐tacrolimus (TAC) after partial liver transplantation (LT) on liver regeneration, rejection, and survival. Methods Based on appropriate dose of EVR + reduced‐TAC in 70% hepatectomy (Experiment 1), allogeneic 30% partial LT (Experiment 2) and whole LT (Experiment 3) were performed. Results After partial LT in EVR + reduced‐TAC therapy, restoration of liver graft weight (to that of the whole liver) was delayed compared with standard dose TAC monotherapy (standard‐TAC) on day 3 (59.3% vs. 72.9%; p 
ISSN:1868-6974
1868-6982
DOI:10.1002/jhbp.1310