Collagen hydrogel with multiple antimicrobial mechanisms as anti-bacterial wound dressing

Wound infection by multidrug-resistant bacteria seriously threatens human life. Chronic wounds, with necrosis, persistent inflammation, and covered by hypoxic tissue, seriously hinder anti-infection treatments. Herein, we have developed a multifunctional hydrogel dressing with antibacterial activity...

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Bibliographic Details
Published in:International journal of biological macromolecules 2023-03, Vol.232, p.123413-123413, Article 123413
Main Authors: Wang, Xun, Zhao, Donghui, Li, Yuting, Zhou, Xinpei, Hui, Zexuan, Lei, Xiaoling, Qiu, Lin, Bai, Yang, Wang, Cheng, Xia, Jiang, Xuan, Yang, Jiang, Pengju, Wang, Jianhao
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - pharmacology
Anti-Infective Agents
Antimicrobial peptides
Bandages
Collagen
Collagen Type III
Humans
Hydrogel dressing
Hydrogels - pharmacology
Hypoxia
Liposomes
Photodynamic therapy
Photothermal therapy
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Summary:Wound infection by multidrug-resistant bacteria seriously threatens human life. Chronic wounds, with necrosis, persistent inflammation, and covered by hypoxic tissue, seriously hinder anti-infection treatments. Herein, we have developed a multifunctional hydrogel dressing with antibacterial activity in the hypoxia environment to promote wound healing. The hydrogel comprises Cypate-conjugated antimicrobial peptides (AMP-Cypates), liposome-encapsulated perfluorodecalin, and recombinant type III collagen. AMP-Cypates exhibited outstanding antibacterial activity, jointly achieved through antimicrobial peptide (AMP) activity, photothermal therapy (PTT), and photodynamic therapy (PDT). The perfluorodecalin liposomes act as the oxygen carrier to mitigate wound hypoxia condition and enhance the efficacy of PDT. The recombinant type III collagen in the hydrogel further promoted the healing of the wounds together with the eradication of bacterial infection. Taken together, the hydrogel dressing provides a platform for integrating multiple antimicrobial mechanisms for the rapid removal of bacterial infection and the healing of chronic wounds. •The wound dressing with antimicrobial mechanisms including antimicrobial peptides, PDT and PTT.•The wound dressing could accelerate wound healing through providing O2 and recombinant type III collagen.•The released O2 can enhance the PDT effect, and significantly improve hypoxic microenvironment to accelerate wound healing.
ISSN:0141-8130
1879-0003
DOI:10.1016/j.ijbiomac.2023.123413