Extensive and Differential Deterioration of Hip Muscles May Preexist in Older Adults with Hip Fractures: Evidence from a Cross-Sectional Study

• Published in: Calcified tissue international 2023-03, Vol.112 (3), p.328-337
• Main Authors: Ling, Ming, Huang, Hou, Li, Xianlong, Xu, Yueyang, Fan, Yongqian
• Format: Article
• Language: English
• Subjects: Aged; Biochemistry; Biomedical and Life Sciences; Bone Density - physiology; Cell Biology; Cross-Sectional Studies; Endocrinology; Hip; Hip Fractures; Humans; Life Sciences; Muscle, Skeletal; Original Research; Orthopedics
• ISSN: 1432-0827; 1432-0827
• DOI: 10.1007/s00223-022-01043-2

Hip muscles play an increasingly important role in lower limb function with aging. Investigating the deterioration of hip muscles and its relationship with hip fracture (HF) may help identify older adults prone to fall. In this study, patients with fall-related HF within 48 h and non-fracture controls aged ≥ 60 years were enrolled. The cross-sectional area (size) and attenuation (density) of the hip flexors, extensors, adductors, and abductors were calculated after segmentation on computed tomography images. The correlation of muscle parameters with HF and age were evaluated using logistic and multiple regression, respectively. Discrimination of HF was analyzed by receiver-operating characteristic analyses. A total of 220 patients and 91 controls were included. The size of the flexors, extensors, and abductors, and the density of the flexors, adductors, and abductors were lower in patients with HF after adjustment for sex, age, and body mass index (BMI). However, decreased muscle size was only observed in hip extensors in patients aged 60–74 years. Decreased muscle size was associated with HF independent of sex, age, BMI, and hip trabecular bone mineral density. Abductor size exhibited a significantly larger negative correlation with age in patients compared to controls. Including abductor size or all muscle size was effective for discrimination of HF in patients aged ≥ 75 years. In conclusion, older adults with HF may have sustained extensive and differential hip muscle deterioration before the injury; extensor atrophy in younger-old age and consideration of a closer relationship between abductor size and age deserve attention.