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Effect of fractional laser alone or in combination on alopecia areata: A systematic review and meta‐analysis
Background Alopecia areata (AA) is characterized by limited non‐scarring patchy alopecia, which appears as round or oval patches and is prone to recurrence, causing severe psychological burdens to patients. No specific device has been approved by the FDA for the treatment of baldness, but new treatm...
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| Published in: | Journal of cosmetic dermatology 2023-05, Vol.22 (5), p.1528-1535 |
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| container_end_page | 1535 |
| container_issue | 5 |
| container_start_page | 1528 |
| container_title | Journal of cosmetic dermatology |
| container_volume | 22 |
| creator | Shen, Yuqing Sun, Jiayi Zhu, Yuqi Chen, Yi Hu, Yebei Luo, Haixin Song, Xiuzu |
| description | Background
Alopecia areata (AA) is characterized by limited non‐scarring patchy alopecia, which appears as round or oval patches and is prone to recurrence, causing severe psychological burdens to patients. No specific device has been approved by the FDA for the treatment of baldness, but new treatments are being investigated and treatments such as the excimer laser, He‐ Ne laser, and excimer lamp have been proposed. A growing number of studies have found that fractional lasers also have great potential in the treatment of AA.
Methods
A literature search and meta‐analysis using Review Manager 5.4 software to investigate the efficacy of fractional laser treatment for AA.
Results
Fractional laser combined with minoxidil (RR 1.32, 95% CI 1.17–1.49, p |
| doi_str_mv | 10.1111/jocd.15630 |
| format | article |
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Alopecia areata (AA) is characterized by limited non‐scarring patchy alopecia, which appears as round or oval patches and is prone to recurrence, causing severe psychological burdens to patients. No specific device has been approved by the FDA for the treatment of baldness, but new treatments are being investigated and treatments such as the excimer laser, He‐ Ne laser, and excimer lamp have been proposed. A growing number of studies have found that fractional lasers also have great potential in the treatment of AA.
Methods
A literature search and meta‐analysis using Review Manager 5.4 software to investigate the efficacy of fractional laser treatment for AA.
Results
Fractional laser combined with minoxidil (RR 1.32, 95% CI 1.17–1.49, p < 0.00001) or cortisol (RR 1.39, 95% CI 1.15–1.67, p = 0.00006) was more effective than either drug alone in the treatment of AA. Of course, the fractional laser alone was also effective in the treatment of AA (RR 10.33, 95% CI 2.07–51.36, p = 0.004) and more effective than cortisol alone (RR 1.86, 95% CI 1.36–2.52, p < 0.00001), and there was no effect on the occurrence of adverse effects (p = 0.49 > 0.05). When compared to other physical treatments of a comparable kind, fractional laser therapy's effectiveness was not significantly different (p = 0.15 > 0.05).
Conclusion
Our results show that the use of fractional lasers can effectively treat alopecia areata.</description><identifier>ISSN: 1473-2130</identifier><identifier>EISSN: 1473-2165</identifier><identifier>DOI: 10.1111/jocd.15630</identifier><identifier>PMID: 36718837</identifier><language>eng</language><publisher>England: John Wiley & Sons, Inc</publisher><subject>Alopecia ; Alopecia - drug therapy ; alopecia areata ; Alopecia Areata - drug therapy ; Aluminum ; Baldness ; Clinical trials ; fractional laser ; Hair loss ; Hormones ; Humans ; Hydrocortisone ; Lasers ; Lasers, Excimer - therapeutic use ; Quality of life ; Software reviews ; Systematic review ; Treatment Outcome</subject><ispartof>Journal of cosmetic dermatology, 2023-05, Vol.22 (5), p.1528-1535</ispartof><rights>2023 The Authors. published by Wiley Periodicals LLC.</rights><rights>2023 The Authors. Journal of Cosmetic Dermatology published by Wiley Periodicals LLC.</rights><rights>2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the "License"). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3520-52a4abbdbfb33e30b5cd0474014c6bb16648df84dce0314f8a0e7852100ab1663</cites><orcidid>0000-0003-3489-7138 ; 0000-0002-9609-5109</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjocd.15630$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/3090613656?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,11562,25753,27924,27925,37012,37013,44590,46052,46476</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36718837$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shen, Yuqing</creatorcontrib><creatorcontrib>Sun, Jiayi</creatorcontrib><creatorcontrib>Zhu, Yuqi</creatorcontrib><creatorcontrib>Chen, Yi</creatorcontrib><creatorcontrib>Hu, Yebei</creatorcontrib><creatorcontrib>Luo, Haixin</creatorcontrib><creatorcontrib>Song, Xiuzu</creatorcontrib><title>Effect of fractional laser alone or in combination on alopecia areata: A systematic review and meta‐analysis</title><title>Journal of cosmetic dermatology</title><addtitle>J Cosmet Dermatol</addtitle><description>Background
Alopecia areata (AA) is characterized by limited non‐scarring patchy alopecia, which appears as round or oval patches and is prone to recurrence, causing severe psychological burdens to patients. No specific device has been approved by the FDA for the treatment of baldness, but new treatments are being investigated and treatments such as the excimer laser, He‐ Ne laser, and excimer lamp have been proposed. A growing number of studies have found that fractional lasers also have great potential in the treatment of AA.
Methods
A literature search and meta‐analysis using Review Manager 5.4 software to investigate the efficacy of fractional laser treatment for AA.
Results
Fractional laser combined with minoxidil (RR 1.32, 95% CI 1.17–1.49, p < 0.00001) or cortisol (RR 1.39, 95% CI 1.15–1.67, p = 0.00006) was more effective than either drug alone in the treatment of AA. Of course, the fractional laser alone was also effective in the treatment of AA (RR 10.33, 95% CI 2.07–51.36, p = 0.004) and more effective than cortisol alone (RR 1.86, 95% CI 1.36–2.52, p < 0.00001), and there was no effect on the occurrence of adverse effects (p = 0.49 > 0.05). When compared to other physical treatments of a comparable kind, fractional laser therapy's effectiveness was not significantly different (p = 0.15 > 0.05).
Conclusion
Our results show that the use of fractional lasers can effectively treat alopecia areata.</description><subject>Alopecia</subject><subject>Alopecia - drug therapy</subject><subject>alopecia areata</subject><subject>Alopecia Areata - drug therapy</subject><subject>Aluminum</subject><subject>Baldness</subject><subject>Clinical trials</subject><subject>fractional laser</subject><subject>Hair loss</subject><subject>Hormones</subject><subject>Humans</subject><subject>Hydrocortisone</subject><subject>Lasers</subject><subject>Lasers, Excimer - therapeutic use</subject><subject>Quality of life</subject><subject>Software reviews</subject><subject>Systematic review</subject><subject>Treatment Outcome</subject><issn>1473-2130</issn><issn>1473-2165</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>PIMPY</sourceid><recordid>eNp9kdFKHDEUhoMo1dre-AAS8EaEtTmTmcls75bVVovgTXsdTjInkGVmsk1mK3vXR-gz-iRmuuqFF4YDOfB_fIT8jJ2AuIR8vqyCbS-hqqXYY0dQKjkroK72X3cpDtnHlFZCgJpD9YEdylpB00h1xIZr58iOPDjuItrRhwE73mGiyLELA_EQuR-4Db3xA045z5OjNVmPHCPhiF_5gqdtGqnPhOWR_nh64Di0vKcRH__-w2zdJp8-sQOHXaLPz_cx-_Xt-ufyZnZ3__12ubibWVkVYlYVWKIxrXFGSpLCVLYVpSoFlLY2Buq6bFrXlK0lIaF0DQpSTVWAEDil8pid77zrGH5vKI2698lS1-FAYZN0oRRIWSiYZ_TsDboKm5jfm7QUc1GDrKtJeLGjbAwpRXJ6HX2PcatB6KkFPbWg_7eQ4dNn5cb01L6iL9-eAdgBD76j7Tsq_eN-ebWTPgHtO5Ky</recordid><startdate>202305</startdate><enddate>202305</enddate><creator>Shen, Yuqing</creator><creator>Sun, Jiayi</creator><creator>Zhu, Yuqi</creator><creator>Chen, Yi</creator><creator>Hu, Yebei</creator><creator>Luo, Haixin</creator><creator>Song, Xiuzu</creator><general>John Wiley & Sons, Inc</general><scope>24P</scope><scope>WIN</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-3489-7138</orcidid><orcidid>https://orcid.org/0000-0002-9609-5109</orcidid></search><sort><creationdate>202305</creationdate><title>Effect of fractional laser alone or in combination on alopecia areata: A systematic review and meta‐analysis</title><author>Shen, Yuqing ; Sun, Jiayi ; Zhu, Yuqi ; Chen, Yi ; Hu, Yebei ; Luo, Haixin ; Song, Xiuzu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3520-52a4abbdbfb33e30b5cd0474014c6bb16648df84dce0314f8a0e7852100ab1663</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Alopecia</topic><topic>Alopecia - drug therapy</topic><topic>alopecia areata</topic><topic>Alopecia Areata - drug therapy</topic><topic>Aluminum</topic><topic>Baldness</topic><topic>Clinical trials</topic><topic>fractional laser</topic><topic>Hair loss</topic><topic>Hormones</topic><topic>Humans</topic><topic>Hydrocortisone</topic><topic>Lasers</topic><topic>Lasers, Excimer - therapeutic use</topic><topic>Quality of life</topic><topic>Software reviews</topic><topic>Systematic review</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shen, Yuqing</creatorcontrib><creatorcontrib>Sun, Jiayi</creatorcontrib><creatorcontrib>Zhu, Yuqi</creatorcontrib><creatorcontrib>Chen, Yi</creatorcontrib><creatorcontrib>Hu, Yebei</creatorcontrib><creatorcontrib>Luo, Haixin</creatorcontrib><creatorcontrib>Song, Xiuzu</creatorcontrib><collection>Wiley Open Access</collection><collection>Wiley Online Library Free Content</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cosmetic dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shen, Yuqing</au><au>Sun, Jiayi</au><au>Zhu, Yuqi</au><au>Chen, Yi</au><au>Hu, Yebei</au><au>Luo, Haixin</au><au>Song, Xiuzu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of fractional laser alone or in combination on alopecia areata: A systematic review and meta‐analysis</atitle><jtitle>Journal of cosmetic dermatology</jtitle><addtitle>J Cosmet Dermatol</addtitle><date>2023-05</date><risdate>2023</risdate><volume>22</volume><issue>5</issue><spage>1528</spage><epage>1535</epage><pages>1528-1535</pages><issn>1473-2130</issn><eissn>1473-2165</eissn><abstract>Background
Alopecia areata (AA) is characterized by limited non‐scarring patchy alopecia, which appears as round or oval patches and is prone to recurrence, causing severe psychological burdens to patients. No specific device has been approved by the FDA for the treatment of baldness, but new treatments are being investigated and treatments such as the excimer laser, He‐ Ne laser, and excimer lamp have been proposed. A growing number of studies have found that fractional lasers also have great potential in the treatment of AA.
Methods
A literature search and meta‐analysis using Review Manager 5.4 software to investigate the efficacy of fractional laser treatment for AA.
Results
Fractional laser combined with minoxidil (RR 1.32, 95% CI 1.17–1.49, p < 0.00001) or cortisol (RR 1.39, 95% CI 1.15–1.67, p = 0.00006) was more effective than either drug alone in the treatment of AA. Of course, the fractional laser alone was also effective in the treatment of AA (RR 10.33, 95% CI 2.07–51.36, p = 0.004) and more effective than cortisol alone (RR 1.86, 95% CI 1.36–2.52, p < 0.00001), and there was no effect on the occurrence of adverse effects (p = 0.49 > 0.05). When compared to other physical treatments of a comparable kind, fractional laser therapy's effectiveness was not significantly different (p = 0.15 > 0.05).
Conclusion
Our results show that the use of fractional lasers can effectively treat alopecia areata.</abstract><cop>England</cop><pub>John Wiley & Sons, Inc</pub><pmid>36718837</pmid><doi>10.1111/jocd.15630</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-3489-7138</orcidid><orcidid>https://orcid.org/0000-0002-9609-5109</orcidid><oa>free_for_read</oa></addata></record> |
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| source | Publicly Available Content Database; Wiley Open Access |
| subjects | Alopecia Alopecia - drug therapy alopecia areata Alopecia Areata - drug therapy Aluminum Baldness Clinical trials fractional laser Hair loss Hormones Humans Hydrocortisone Lasers Lasers, Excimer - therapeutic use Quality of life Software reviews Systematic review Treatment Outcome |
| title | Effect of fractional laser alone or in combination on alopecia areata: A systematic review and meta‐analysis |
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