Bias-force guided simulations combined with experimental validations towards GPR17 modulators identification

Glioblastoma Multiforme (GBM) is known to be by far the most aggressive brain tumor to affect adults. The median survival rate of GBM patient’s is

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Bibliographic Details
Published in:Biomedicine & pharmacotherapy 2023-04, Vol.160, p.114320-114320, Article 114320
Main Authors: Kari, Sana, Murugesan, Akshaya, Thiyagarajan, Ramesh, Kidambi, Srivatsan, Razzokov, Jamoliddin, Selvaraj, Chandrabose, Kandhavelu, Meenakshisundaram, Marimuthu, Parthiban
Format: Article
Language:English
Subjects:
Bias-force simulation
Forskolin-stimulated cAMP accumulation
GPR17
Humans
Lactones
Orphan-GPCRs
Pyridines
Receptors, G-Protein-Coupled - metabolism
Remyelination
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Description
Summary:Glioblastoma Multiforme (GBM) is known to be by far the most aggressive brain tumor to affect adults. The median survival rate of GBM patient’s is
ISSN:0753-3322
1950-6007
DOI:10.1016/j.biopha.2023.114320