Women with preeclampsia exposed to air pollution during pregnancy: Relationship between oxidative stress and neonatal disease - Pilot study

• Published in: The Science of the total environment 2023-05, Vol.871, p.161858-161858, Article 161858
• Main Authors: Juan-Reyes, Sindy San, Gómez-Oliván, Leobardo Manuel, Juan-Reyes, Nely San, Islas-Flores, Hariz, Dublán-García, Octavio, Orozco-Hernández, José Manuel, Pérez-Álvarez, Itzayana, Mejía-García, Alejandro
• Format: Article
• Language: English
• Subjects: Air Pollutants - analysis; Air Pollutants - toxicity; Air pollution; Air Pollution - adverse effects; Air Pollution - analysis; Antioxidants; Female; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases - chemically induced; Infant, Premature; Maternal Exposure - adverse effects; Newborn diseases; Oxidative Stress; Particulate Matter - analysis; Particulate Matter - toxicity; Pilot Projects; Pre-Eclampsia; Preeclampsia; Pregnancy; Pregnancy Complications; Pregnancy Outcome
• ISSN: 0048-9697; 1879-1026
• DOI: 10.1016/j.scitotenv.2023.161858

Oxidative imbalance as a pathophysiological mechanism has been reported as an adverse outcome in pregnant women who develop preeclampsia and in their newborns. Furthermore, emerging evidence suggests the same mechanism by which air pollutants may exert their toxic effects. Therefore, the objective of the study was to evaluate the biomarkers of oxidative stress and their relationship with neonatal disease in premature newborns from mothers with preeclampsia exposed to air pollution during pregnancy. The data of air pollutants (PM2.5, PM10 and ozone) were collected at fixed monitoring stations. Oxidative and antioxidant status markers were obtained through special techniques in women with preeclampsia and in umbilical cord blood of their premature newborns. The oxidative stress markers were significantly higher in women with preeclampsia and their newborns who were exposed to higher levels of ambient air pollutants in the first and second trimester of pregnancy. Neonatal diseases are associated with preeclampsia in pregnancies, specifically intrauterine growth restriction (IUGR) and necrotizing enterocolitis (NEC). A significant correlation was identified in the levels of prooxidant agents and antioxidant enzyme activity in the presence of neonatal diseases associated with preeclampsia. There is increased oxidative damage in both the maternal and fetal circulation in women who develop preeclampsia exposed to air pollution during pregnancy. Therefore, these pregnancies complicated by preeclampsia have a greater adverse outcome as neonatal disease in the preterm infant. [Display omitted] •Exposure to air pollution induces to oxidative damage and adverse perinatal outcome.•Critical windows of early exposure in preeclamptic pregnancy are identified.•Neonatal diseases are associated with pregnancies that develop preeclampsia.•There is a correlation between oxidative stress markers levels and neonatal diseases.