Characteristics and pathogenesis of chemokines in the post-stroke stage

•Summarizing the chemokine characteristics in the post-stroke stage.•Providing the potential strategies for the treatment of stroke targeting to chemokine.•Reviewing of progress of drug development targeting to chemokine and its receptors. Chemokines, as small molecular proteins, play a crucial role...

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Bibliographic Details
Published in:International immunopharmacology 2023-03, Vol.116, p.109781-109781, Article 109781
Main Authors: Lin, Yu-ting, Chen, Hao-dong, Ai, Qi-di, Yang, Yan-tao, Zhang, Zhao, Chu, Shi-feng, Chen, Nai-hong
Format: Article
Language:English
Subjects:
Chemokine
Chemokine receptor
Chemokines - metabolism
Humans
Nerve repair
Receptors, Chemokine - metabolism
Stroke
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Summary:•Summarizing the chemokine characteristics in the post-stroke stage.•Providing the potential strategies for the treatment of stroke targeting to chemokine.•Reviewing of progress of drug development targeting to chemokine and its receptors. Chemokines, as small molecular proteins, play a crucial role in the immune and inflammatory responses after stroke. A large amount of evidence showed chemokines and their receptors were increasingly recognized as potential targets for stroke treatment, which were involved in the processing of neovascularization, neurogenesis, and neural network reconstruction. In this review, we summarized the characteristics of chemokine alterations throughout the post-stroke nerve repair phase to gain insight into the pathological mechanisms of chemokines and find effective therapeutic targets for stroke.
ISSN:1567-5769
1878-1705
DOI:10.1016/j.intimp.2023.109781