Structural and Functional Changes of the Thoracic Aorta in Experimental Arterial Hypertension

The functional characteristics of the thoracic aorta in Wistar rat with experimental arterial hypertension were studied using MRI. The intravital images of the aorta were obtained using a synchronizer of cardiac and respiratory cycles. The pulse-gradient Turbo-spin-echo sequence and the BODY CARDIAC...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2023, Vol.174 (3), p.308-311
Main Authors: Agafonova, I. G., Kotelnikov, V. N., Geltser, B. I.
Format: Article
Language:English
Subjects:
Animals
Aorta
Aorta, Thoracic - diagnostic imaging
Aortic arch
Biomedical and Life Sciences
Biomedicine
Cell Biology
Endothelium
Heart
Hypertension
Hypertension - diagnostic imaging
Internal Medicine
Laboratory Medicine
Pathology
Rats
Rats, Wistar
Structure-function relationships
Thorax
Vasodilation
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Summary:The functional characteristics of the thoracic aorta in Wistar rat with experimental arterial hypertension were studied using MRI. The intravital images of the aorta were obtained using a synchronizer of cardiac and respiratory cycles. The pulse-gradient Turbo-spin-echo sequence and the BODY CARDIAC movie 10 mode were used. The unfavorable factor of increased BP initiated structural and functional changes in the thoracic aorta. At the initial stages, they manifested by an increase of the lumen and a decrease in endothelium-dependent vasodilation. Progression of arterial hypertension (3-6 months) was associated with narrowing of the lumen of both ascending and descending parts of the aorta. Deformation of the aortic arch due to increased density of the vascular wall was observed by the sixth month of the development of arterial hypertension.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-023-05697-2