Soft robot-enabled controlled release of oral drug formulations

The creation of highly effective oral drug delivery systems (ODDSs) has long been the main objective of pharmaceutical research. Multidisciplinary efforts involving materials, electronics, control, and pharmaceutical sciences encourage the development of robot-enabled ODDSs. Compared with convention...

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Bibliographic Details
Published in:Soft matter 2023-02, Vol.19 (7), p.1269-1281
Main Authors: Huang, Hao, Lyu, Yidan, Nan, Kewang
Format: Article
Language:English
Subjects:
Biocompatibility
Controlled release
Delayed-Action Preparations
Drug Compounding
Drug delivery
Drug delivery systems
Kinetics
Maneuverability
Oral administration
Pharmaceuticals
Robotics
Robots
Shape control
Soft robotics
State-of-the-art reviews
System effectiveness
Tissues
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Summary:The creation of highly effective oral drug delivery systems (ODDSs) has long been the main objective of pharmaceutical research. Multidisciplinary efforts involving materials, electronics, control, and pharmaceutical sciences encourage the development of robot-enabled ODDSs. Compared with conventional rigid robots, soft robots potentially offer better mechanical compliance and biocompatibility with biological tissues, more versatile shape control and maneuverability, and multifunctionality. In this paper, we first describe and highlight the importance of manipulating drug release kinetics, i.e. pharmaceutical kinetics. We then introduce an overview of state-of-the-art soft robot-based ODDSs comprising resident, shape-programming, locomotive, and integrated soft robots. Finally, the challenges and outlook regarding future soft robot-based ODDS development are discussed. The creation of highly effective oral drug delivery systems (ODDSs) has long been the main objective of pharmaceutical research.
ISSN:1744-683X
1744-6848
DOI:10.1039/d2sm01624a