2,2′,4,4′,5,5′-Hexabromophenyl ether (BDE-153) causes abnormal insulin secretion and disorders of glucose and lipid metabolism in mice

Environmental polybrominated diphenyl ether (PBDE) exposure may be associated with diabetes and obesity. 2,2',4,4',5,5'-Hexabromodiphenyl ether (BDE-153) is one of the most abundant and widely distributed homologs of PBDEs detected in humans. This study investigated the effects of BDE...

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Bibliographic Details
Published in:Journal of the Chinese Medical Association 2023-04, Vol.86 (4), p.388-398
Main Authors: Liu, Zao-Ling, Jiang, Shu-Rui, Fan, Yong, Wang, Jia-Sui, Wang, Meng-Lin, Li, Mei-Yan
Format: Article
Language:English
Subjects:
Adipokines - metabolism
Adult
Animals
Ether
Ethers
Ethyl Ethers
Glucose
Humans
Insulin - metabolism
Insulin Secretion
Lipid Metabolism
Male
Mice
Mice, Inbred C57BL
PPAR gamma
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Summary:Environmental polybrominated diphenyl ether (PBDE) exposure may be associated with diabetes and obesity. 2,2',4,4',5,5'-Hexabromodiphenyl ether (BDE-153) is one of the most abundant and widely distributed homologs of PBDEs detected in humans. This study investigated the effects of BDE-153 on the expression of adipokines and glucose and lipid metabolism. Adult male C57BL/6 mice were divided into five BDE-153 groups and one control group. After BDE-153 exposure for 4 weeks, the levels of biochemical indexes and the mRNA and protein expression levels of leptin, adiponectin, peroxisome proliferators activated receptors gamma (PPARγ), and AMPKα were measured. The histomorphological changes of liver and pancreas tissues were observed. After BDE-153 exposure, the weight of mice in the medium-high-dose group at different exposure times was lower than that in the control group ( p all
ISSN:1726-4901
1728-7731
DOI:10.1097/JCMA.0000000000000886