ent‐Pimarane Diterpenes from the Aerial Parts of Siegesbeckia pubescens

Five new ent‐pimarane diterpenes (1–5) and five known analogs (6–10) were isolated from the aerial parts of Siegesbeckia pubescens. Their structures, including absolute configurations, were determined by comprehensive spectroscopic methods especially 1D and 2D NMR and quantum chemical electronic cir...

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Bibliographic Details
Published in:Chemistry & biodiversity 2023-03, Vol.20 (3), p.e202201090-n/a
Main Authors: Liu, Na, Luo, Ting‐ting, Wu, Cong, Sun, Yu‐lin, Wang, Peng, Zhang, Hua, Ge, Di
Format: Article
Language:English
Subjects:
Abietanes - chemistry
Abietanes - pharmacology
Circular dichroism
Cytotoxicity
Dichroism
Diterpenes
Diterpenes - chemistry
Diterpenes - pharmacology
ent-pimarane
Humans
Lung cancer
Molecular Structure
NMR
Nuclear magnetic resonance
Plant Components, Aerial - chemistry
Quantum chemistry
Siegesbeckia pubescens
Sigesbeckia - chemistry
Toxicity
Tumor cell lines
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Summary:Five new ent‐pimarane diterpenes (1–5) and five known analogs (6–10) were isolated from the aerial parts of Siegesbeckia pubescens. Their structures, including absolute configurations, were determined by comprehensive spectroscopic methods especially 1D and 2D NMR and quantum chemical electronic circular dichroism calculations. All the isolated compounds were evaluated for their cytotoxicity against human BT549, A549 and H157 cancer cell lines. Among them, compounds 1 and 2 showed mild cytotoxicity against lung cancer cell lines H157 with IC50 values of 16.35±2.59 and 18.86±4.83 μM, respectively.
ISSN:1612-1872
1612-1880
DOI:10.1002/cbdv.202201090