Vascular Responses to Passive and Active Movement in Premenopausal Females: Comparisons across Sex and Menstrual Cycle Phase

• Published in: Medicine and science in sports and exercise 2023-05, Vol.55 (5), p.900-910
• Main Authors: WEGGEN, JENNIFER B., HOGWOOD, AUSTIN C., DECKER, KEVIN P., DARLING, ASHLEY M., CHIU, ALEX, RICHARDSON, JACOB, GARTEN, RYAN S.
• Format: Article
• Language: English
• Subjects: Brachial Artery - physiology; Female; Hand Strength - physiology; Hemodynamics; Humans; Male; Menstrual Cycle; Movement; Regional Blood Flow - physiology; Vasodilation - physiology
• ISSN: 0195-9131; 1530-0315
• DOI: 10.1249/MSS.0000000000003107

Adequate, robust vascular responses to passive and active movement represent two distinct components linked to normal, healthy cardiovascular function. Currently, limited research exists determining if these vascular responses are altered in premenopausal females (PMF) when compared across sex or menstrual cycle phase. Vascular responses to passive leg movement (PLM) and handgrip (HG) exercise were assessed in PMF ( n = 21) and age-matched men ( n = 21). A subset of PMF subjects ( n = 11) completed both assessments during the early and late follicular phase of their menstrual cycle. Microvascular function was assessed during PLM via changes in leg blood flow, and during HG exercise, via steady-state arm vascular conductance. Macrovascular (brachial artery [BA]) function was assessed during HG exercise via BA dilation responses as well as BA shear rate-dilation slopes. Leg microvascular function, determined by PLM, was not different between sexes or across menstrual cycle phase. However, arm microvascular function, demonstrated by arm vascular conductance, was lower in PMF compared with men at rest and during HG exercise. Macrovascular function was not different between sexes or across menstrual cycle phase. This study identified similar vascular function across sex and menstrual cycle phase seen in microvasculature of the leg and macrovascular (BA) of the arm. Although arm microvascular function was unaltered by menstrual cycle phase in PMF, it was revealed to be significantly lower when compared with age-matched men highlighting a sex difference in vascular/blood flow regulation during small muscle mass exercise.