Analysis of prognostic factors in patients with self-expandable metallic stents for treatment of malignant gastric outlet obstruction

Self-expandable metallic stents (SEMSs) are widely accepted as a less-invasive treatment for malignant gastric outlet obstruction (GOO). However, the factors related to prognosis and stent dysfunction after SEMS placement are not well known, and we aimed to investigate them. This was a single-center...

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Bibliographic Details
Published in:Scandinavian journal of gastroenterology 2023-07, Vol.58 (7), p.822-829
Main Authors: Nakano, Yoshiko, Mizumoto, Yoshinori, Endoh, Bunji, Shimogama, Tsubasa, Iwamoto, Satoru, Esaka, Naoki, Ohta, Yoshiyuki, Murai, Katsuyuki, Murata, Masaki, Miyamoto, Shin'ichi
Format: Article
Language:English
Subjects:
chemotherapy
Gastric Outlet Obstruction - etiology
Gastric Outlet Obstruction - surgery
Humans
Malignant gastric outlet obstruction
overall survival
Palliative Care
Pancreatic Neoplasms
Pancreatic Neoplasms - complications
Prognosis
Retrospective Studies
Self Expandable Metallic Stents - adverse effects
self-expandable metallic stents
Stents - adverse effects
Stomach Neoplasms - complications
time to recurrent gastric outlet obstruction
Treatment Outcome
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Summary:Self-expandable metallic stents (SEMSs) are widely accepted as a less-invasive treatment for malignant gastric outlet obstruction (GOO). However, the factors related to prognosis and stent dysfunction after SEMS placement are not well known, and we aimed to investigate them. This was a single-center retrospective cohort study of 212 malignant strictures in 207 patients. Factors related to prolonged overall survival (OS) and time to recurrent GOO (TRGOO) after SEMS placement were evaluated. Improvement of oral intake was confirmed in 179 patients (86%). The median OS was 65 days. A Cox proportional hazards model revealed that lower cancer stage, lower performance status score at the time of SEMS placement, and administration of chemotherapy after SEMS placement were significant predictive factors for prolonged OS. The median OS was 182 days in the group of SEMS followed by chemotherapy (group A) and 43 days in the group of SEMS alone (group B) (p
ISSN:0036-5521
1502-7708
DOI:10.1080/00365521.2023.2173534