Triterpenoids from the leaves of Abies koreana and their biological activities

Seven undescribed triterpenoids, abikoranes A–G, along with three known triterpenoids were isolated from the leaves of Abies koreana E. H. Wilson. The structures of compounds were elucidated by 1D and 2D NMR, HRMS, ECD, specific rotation, and DP4+ analysis. Abikorane A represents the second example...

Full description

Saved in:
Bibliographic Details
Published in:Phytochemistry (Oxford) 2023-04, Vol.208, p.113594-113594, Article 113594
Main Authors: Lee, Dong Jun, Hong, Seong-Min, Yoon, Da Hye, Ham, Song Lim, Kim, Jonghwan, Kim, Sun Yeou, Choi, Sang Un, Kim, Chung Sub, Lee, Kang Ro
Format: Article
Language:English
Subjects:
Abies - chemistry
Abies koreana
Anti-neuroinflammation
Cytotoxic
Magnetic Resonance Spectroscopy
Molecular Structure
Neurotrophic
Pinaceae
Plant Leaves
Triterpenes - chemistry
Triterpenoid
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Seven undescribed triterpenoids, abikoranes A–G, along with three known triterpenoids were isolated from the leaves of Abies koreana E. H. Wilson. The structures of compounds were elucidated by 1D and 2D NMR, HRMS, ECD, specific rotation, and DP4+ analysis. Abikorane A represents the second example of nor-3,4-seco-17,14-friedo-lanostane triterpenoid. Among the isolates, some compounds showed strong cytotoxic activities against some of four tested cancer cell lines (A549, SK-OV-3, SK-MEL-2, and HCT-116) with the values of IC50 0.89–9.62 μM, inhibited lipopolysaccharide-stimulated nitric oxide production with IC50 values of 11.57–15.16 μM, and exhibited significant nerve growth factor release effect (192.54 ± 12.33%) from C6 glioma cells. Cytotoxic, anti-inflammatory, and neurotrophic triterpenoids were isolated and structurally characterized from Abies koreana. [Display omitted] •Seven undescribed triterpenoids were isolated from the twigs of A. koreana.•The structures were elucidated by NMR, HRMS, and computation.•Abikoreane A have a nor-3,4-seco-17,14-friedo-lanostane triterpenoid scaffold.•Some compounds showed cytotoxic, anti-inflammatory, and/or neurotrophic activities.
ISSN:0031-9422
1873-3700
DOI:10.1016/j.phytochem.2023.113594