Transatlantic progress in measurement of cognitive outcomes in paediatric oncology trials

The importance of measuring quality of survival within paediatric oncology trials is increasingly recognised. However, capturing neuropsychological outcomes and other aspects of quality of survival in the context of large or multinational trials can be challenging. We provide examples of protocols d...

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Bibliographic Details
Published in:Pediatric blood & cancer 2023-05, Vol.70 (5), p.e30171-n/a
Main Authors: Thomas, Sophie, Embry, Leanne, Walsh, Karin, Bull, Kim, Grundy, Richard, Kennedy, Colin, Lemiere, Jurgen, Hernáiz Driever, Pablo, Limond, Jennifer, Chevignard, Mathilde, Hardy, Kristina
Format: Article
Language:English
Subjects:
Brain cancer
brain tumour
cancer
Child
Clinical trials
Cognition
cognitive
Cognitive ability
Europe
Humans
late effects
Medical Oncology
Neoplasms - drug therapy
Oncology
paediatric
Pediatrics
quality of survival
Survival
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Summary:The importance of measuring quality of survival within paediatric oncology trials is increasingly recognised. However, capturing neuropsychological outcomes and other aspects of quality of survival in the context of large or multinational trials can be challenging. We provide examples of protocols designed to address this challenge recently employed in clinical trials in the USA and Europe. We discuss their respective strengths and challenges, obstacles encountered and future opportunities for transatlantic collaboration.
ISSN:1545-5009
1545-5017
DOI:10.1002/pbc.30171