The Functional Role of LncRNA UCA1 in Pancreatic Cancer: a mini-review

Pancreatic cancer (PaC) is a common malignant tumor of the digestive tract, with a 5-year survival rate of less than 5% and high mortality rate in the world. LncRNAs have been showed to possess multiple biological functions in growth, differentiation, and proliferation, which play an important role...

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Bibliographic Details
Published in:Journal of Cancer 2023, Vol.14 (2), p.275-280
Main Authors: Sun, Cen-Cen, Li, Li, Jiang, Zhi-Chen, Liu, Zheng-Chuang, Wang, Liang, Wang, Hui-Ju
Format: Article
Language:English
Subjects:
Angiogenesis
Apoptosis
Bladder cancer
Cell cycle
Cell growth
Drug resistance
Gene expression
Hypoxia
Medical prognosis
Metastasis
Mortality
Mutation
Pancreatic cancer
Pathogenesis
Proteins
Tumors
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Summary:Pancreatic cancer (PaC) is a common malignant tumor of the digestive tract, with a 5-year survival rate of less than 5% and high mortality rate in the world. LncRNAs have been showed to possess multiple biological functions in growth, differentiation, and proliferation, which play an important role in different biological processes and diseases, especially in the development of tumors. LncRNA UCA1, which is firstly identified in human bladder cancer, has been showed to be a tumor promoter in pancreatic cancer. Recent researches have showed that UCA1 might promote pancreatic carcinogenesis and progression, and correlate with drug resistance. In this review, we address the biological function and regulatory mechanism of UCA1 in pancreatic cancer, which might give a new approach for clinical diagnosis and treatment.
ISSN:1837-9664
1837-9664
DOI:10.7150/jca.79171