Regulation of lignocellulose degradation in microorganisms

Microbial strategies for biomass deconstruction involve an incredible repertoire of enzymatic, structural, and regulatory proteins. From carbohydrate active enzymes to cellulosomes, bacteria, yeast, and filamentous fungi adapt their functional machinery to grow from alternative carbon sources such a...

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Bibliographic Details
Published in:Journal of applied microbiology 2023-01, Vol.134 (1)
Main Authors: Gurovic, María Soledad Vela, Viceconte, Fatima Regina, Bidegain, Maximiliano Andres, Dietrich, Julián
Format: Article
Language:English
Subjects:
Bacteria - genetics
Bacteria - metabolism
Cellulose - metabolism
Fungi - metabolism
Lignin - metabolism
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Summary:Microbial strategies for biomass deconstruction involve an incredible repertoire of enzymatic, structural, and regulatory proteins. From carbohydrate active enzymes to cellulosomes, bacteria, yeast, and filamentous fungi adapt their functional machinery to grow from alternative carbon sources such as lignocellulose and survive starvation. In that context, microbes must be able to sense, bind, degrade, and utilize lignin, cellulose, and hemicelluloses. Nature has developed specialized protein modules, RNA structures, and regulatory systems operating at a genomic, transcription, and translation level. This review briefly summarizes the main regulatory pathways involved in lignocellulose microbial degradation, including carbon catabolite repression; anti-sigma factors; regulatory RNA elements such as small RNAs, antisense RNA, RNA-binding proteins, and selective RNA processing and stabilization; and transcriptional regulators and unfolded protein response. Interplay with global regulators controlling pH response and nitrogen utilization is also revised.
ISSN:1365-2672
1365-2672
DOI:10.1093/jambio/lxac002