Efficacy of cEEG and hepatic function to diagnose early acute encephalopathy

• Published in: Pediatrics international 2023-01, Vol.65 (1), p.e15494-n/a
• Main Authors: Sakurai, Yoshio, Osada, Kohei, Sakamoto, Wataru, Uchida, Yuta, Kawano, Akiko, Kobayashi, Shingo, Chikaishi, Maki, Kojima, Hideo, Ozawa, Junichi, Sakai, Hirokazu, Moriwaki, Koichi, Yamanouchi, Hideo
• Format: Article
• Language: English
• Subjects: acute encephalopathy; Blood coagulation; Brain Diseases - diagnosis; coagulopathy; Differential diagnosis; EEG; electroencephalography; Electroencephalography - methods; Electronic medical records; Encephalopathy; Epilepsy; Humans; Intellectual disabilities; Liver; Magnetic resonance imaging; Neuroimaging; Patients; Pediatrics; prognosis; Retrospective Studies; Seizures - diagnosis; status epilepticus; Status Epilepticus - diagnosis
• ISSN: 1328-8067; 1442-200X
• DOI: 10.1111/ped.15494

Background Early treatment may improve the prognosis of acute encephalopathy (AE). However, methods for early diagnosis have not yet been established. In this paper, we examined methods for the early diagnosis of AE. Methods We extracted data on patients with febrile status epilepticus from the electronic medical records in our department between March 2016 and April 2021. Among these, 79 patients who underwent continuous electroencephalography (cEEG) were included in this study. Patients who exhibited psychomotor retardation or abnormal brain magnetic resonance imaging findings were assigned to Group E (n = 20), and the remaining patients were the control group (Group C, n = 59). The following tests were compared retrospectively between these two groups on admission: cEEG, serum hepatic function tests, and blood coagulation tests. Results The percentage of patients who exhibited high‐amplitude slow waves or flat waves on cEEG at the time of admission was statistically significantly higher in Group E than in Group C (p