Novel N-doped carbon dots derived from citric acid and urea: fluorescent sensing for determination of metronidazole and cytotoxicity studies

Blue emitting nitrogen-doped carbon dots were synthesized using citric acid and urea through the hydrothermal method, and the fluorescence quantum yield was 35.08%. We discovered that N-CDs featured excellent robust fluorescence stability and chemical resistance. For metronidazole detection, our N-C...

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Bibliographic Details
Published in:RSC advances 2023-01, Vol.13 (4), p.2663-2671
Main Authors: Qi, Haiyan, Qiu, Lixin, Zhang, Xiaohong, Yi, Tonghui, Jing, Jing, Sami, Rokayya, Alanazi, Sitah F, Alqahtani, Zahrah, Aljabri, Mahmood D, Rahman, Mohammed M
Format: Article
Language:English
Subjects:
Carbon dots
Citric acid
Fluorescence
Nitrogen
Quantum dots
Response time
Selectivity
Toxicity
Ureas
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Summary:Blue emitting nitrogen-doped carbon dots were synthesized using citric acid and urea through the hydrothermal method, and the fluorescence quantum yield was 35.08%. We discovered that N-CDs featured excellent robust fluorescence stability and chemical resistance. For metronidazole detection, our N-CDs exhibited quick response time, high selectivity and sensitivity, and low cytotoxicity. Specifically, our N-CDs could detect metronidazole in the linear range of 0-179 μM, and the LOD was 0.25 μM. Furthermore, metronidazole efficaciously quenches the fluorescence of N-CDs, possibly owing to the inner filter effect. Lastly, we have employed our N-CDs to detect metronidazole in commercial metronidazole tablets with high accuracy. Overall, the newly prepared fluorescence sensor, N-CDs, demonstrated a huge potential to detect metronidazole in a simple, efficient, sensitive, and rapid manner. N-CDs were prepared with a high fluorescence quantum yield of 35.08%. N-CDs have been employed to detect metronidazole in commercial metronidazole tablets. N-CDs exhibited quick response time, high selectivity and sensitivity, and low cytotoxicity.
ISSN:2046-2069
2046-2069
DOI:10.1039/d2ra07150a