A study on the fabrication of porous chitosan/gelatin network scaffold for tissue engineering

A novel porous chitosan/gelatin scaffold for tissue engineering was prepared via polyelectrolyte complex formation, freeze drying and post‐crosslinking with glutaraldehyde. The porosity and mean pore diameters could be controlled within 30∼100 µm by varying the original water content and the freezin...

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Bibliographic Details
Published in:Polymer international 2000-12, Vol.49 (12), p.1596-1599
Main Authors: Shen, F, Cui, Y L, Yang, L F, Yao, K D, Dong, X H, Jia, W Y, Shi, H D
Format: Article
Language:English
Subjects:
Applied sciences
Biomedical engineering
chitosan
Crosslinking
Exact sciences and technology
gelatin
Mechanical properties
Natural polymers
network
network, scaffolds, preparation
Organic compounds
Physicochemistry of polymers
Polyelectrolytes
Porosity
preparation
Proteins
scaffolds
Starch and polysaccharides
Tissue
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Summary:A novel porous chitosan/gelatin scaffold for tissue engineering was prepared via polyelectrolyte complex formation, freeze drying and post‐crosslinking with glutaraldehyde. The porosity and mean pore diameters could be controlled within 30∼100 µm by varying the original water content and the freezing conditions. Dipping the scaffolds in poly(lactic acid) provided good mechanical properties making it a promising candidate towards tissue engineering. © 2000 Society of Chemical Industry
ISSN:0959-8103
1097-0126
DOI:10.1002/1097-0126(200012)49:12<1596::AID-PI553>3.0.CO;2-S