Use of antiepileptic drugs as prophylaxis against posttraumatic seizures in the pediatric population: a systematic review and meta-analysis

We aim to assess the effect of anti-epileptic drug (AED) prophylaxis for early or late posttraumatic seizures, targeting the pediatric population with traumatic brain injury (TBI). We systematically searched for studies reporting the incidence of posttraumatic seizures in pediatric patients who suff...

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Bibliographic Details
Published in:Neurosurgical review 2023-02, Vol.46 (1), p.49-49, Article 49
Main Authors: Samara, Qais A., Ifraitekh, Ali S., Al Jayyousi, Obada, Sawan, Siya, Hazaimeh, Ethar, Jbarah, Omar F.
Format: Article
Language:English
Subjects:
Adult
Anticonvulsants - therapeutic use
Brain Injuries, Traumatic - complications
Brain Injuries, Traumatic - drug therapy
Child
Humans
Levetiracetam - therapeutic use
Medicine
Medicine & Public Health
Neurosurgery
Phenytoin - therapeutic use
Piracetam - therapeutic use
Review
Seizures - drug therapy
Seizures - etiology
Seizures - prevention & control
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Summary:We aim to assess the effect of anti-epileptic drug (AED) prophylaxis for early or late posttraumatic seizures, targeting the pediatric population with traumatic brain injury (TBI). We systematically searched for studies reporting the incidence of posttraumatic seizures in pediatric patients who suffered from TBI and received AEDs prophylactically following their TBI incident. Studies that included adult patients, adult and pediatric patients but did not report results for the pediatric population separately, and patients who did not suffer from a TBI were excluded. Studies that did not indicate the use of antiepileptic drugs prophylactically following TBI were excluded. A total of 10 studies were included involving 4621 posttraumatic brain injury patients of the pediatric age population (
ISSN:1437-2320
1437-2320
DOI:10.1007/s10143-023-01963-z