Photoredox-Catalyzed and Silane-Mediated Hydrofluoromethylation of Unactivated Alkenes with Fluoroiodomethane in Water

The first hydrofluoromethylation of unactivated alkenes with fluoroiodomethane and hydrosilanes is developed by merging photoredox catalysis and silane-mediated deiodination processes. The key to the success of this reaction is the use of water as the solvent to enhance the activity of CH2F radical...

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Bibliographic Details
Published in:Organic letters 2023-02, Vol.25 (6), p.1035-1039
Main Authors: Hu, Chen-Chen, Tong, Chao-Lai, Zhang, Yu-Yang, Xu, Xiu-Hua, Qing, Feng-Ling
Format: Article
Language:English
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Summary:The first hydrofluoromethylation of unactivated alkenes with fluoroiodomethane and hydrosilanes is developed by merging photoredox catalysis and silane-mediated deiodination processes. The key to the success of this reaction is the use of water as the solvent to enhance the activity of CH2F radical toward unactivated alkenes.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.3c00260