Oxidative carbonylation of N -protected indoles by Rh(III)-zeolites

The oxidative carbonylation of -protected indoles was investigated to directly synthesize indole-3-carboxylic acids. Using Rh(III)-zeolites as heterogeneous catalysts, the single-site Rh-species reach unprecedented activities (>100 turnovers), while the metal is readily recovered after reaction....

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2023-02, Vol.59 (16), p.2319-2322
Main Authors: Van Minnebruggen, Sam, Marquez, Carlos, Krasniqi, Besir, Janssens, Kwinten, Van Velthoven, Niels, Vercammen, Jannick, De Soete, Benoit, Bugaev, Aram, De Vos, Dirk
Format: Article
Language:English
Subjects:
Absorption spectroscopy
Carbonyls
Carboxylic acids
Indoles
Rhodium
X ray absorption
Zeolites
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Summary:The oxidative carbonylation of -protected indoles was investigated to directly synthesize indole-3-carboxylic acids. Using Rh(III)-zeolites as heterogeneous catalysts, the single-site Rh-species reach unprecedented activities (>100 turnovers), while the metal is readily recovered after reaction. X-ray absorption spectroscopy (XAS) provided evidence for site-isolation of Rh(III) species on the zeolite.
ISSN:1359-7345
1364-548X
DOI:10.1039/d2cc05953c