Prediction of Recurrence of Atrial Fibrillation Post-ablation Based on Atrial Fibrosis Seen on Late Gadolinium Enhancement MRI: A Metaanalysis

Objectives: This meta-analysis aims to investigate the recurrence of atrial fibrillation (AF) post-ablation based on the various stages of fibrosis seen in the late gadolinium enhancement magnetic resonance imaging (LGE-MRI). Methods: Electronic databases were searched using specific terms and ident...

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Bibliographic Details
Published in:Current cardiology reviews 2023, Vol.19 (3), p.e051222211571-e051222211571
Main Authors: Regmi, Manjari Rani, Bhattarai, Mukul, Parajuli, Priyanka, Botchway, Albert, Tandan, Nitin, Abdelkarim, Jumana, Labedi, Mohamed
Format: Article
Language:English
Subjects:
Ablation
Atrial Fibrillation - diagnostic imaging
Atrial Fibrillation - surgery
Cardiac arrhythmia
Catheter Ablation - methods
Contrast Media
Fibrillation
Fibrosis
Gadolinium
Heart Atria - diagnostic imaging
Humans
Magnetic resonance imaging
Magnetic Resonance Imaging - methods
Medical instruments
Recurrence
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Summary:Objectives: This meta-analysis aims to investigate the recurrence of atrial fibrillation (AF) post-ablation based on the various stages of fibrosis seen in the late gadolinium enhancement magnetic resonance imaging (LGE-MRI). Methods: Electronic databases were searched using specific terms and identified nine studies that met the inclusion criteria. A total of 1,787 patients underwent LGE-MRI to assess atrial fibrosis before catheter ablation for AF. We performed three analyses: first, we compared stage IV versus stage I (reference group). The second set examined the combined stages III and IV versus stages I and II (reference group). The third set compared stage IV versus combined stages I, II, and III. The metanalysis relied on a random-effects model to pool the odds ratios (OR) and 95% confidence intervals (CI) using the DerSimonian and Laird method. The data was analyzed using StatsDirect software in England. Results: The study showed a higher rate of AF recurrence after ablation in stage IV atrial fibrosis than in stage I (OR, 9.54; 95% CI, 3.81 to 28.89; P
ISSN:1573-403X
1875-6557
DOI:10.2174/1573403X19666221205100148