The combined use of carbon nanotubes with synthetic ceramics enhances posterolateral fusion: an experimental study in a rat spinal fusion model

Purpose The aim of the present study was to evaluate the effectiveness of carbon nanotubes (CNTs)/ HA–tricalcium phosphate (TCP) composite in a posterolateral spinal fusion model. Methods At first, CNTs and CNTs/HA–TCP composites were prepared. Twenty adult male Sprague Dawley rats were randomized i...

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Bibliographic Details
Published in:Spine deformity 2023-07, Vol.11 (4), p.805-814
Main Authors: Daldal, Ismail, Senkoylu, Alpaslan, Degim, Ismail Tuncer, Ilbasmıs Tamer, Sibel, Omeroglu, Suna, Akarca Dizakar, Saadet Ozen, Celik, Hakan Hamdi, Uzuner, Muhammet Bora, Kurtoglu, Alper, Yapar, Dilek, Yapar, Aliekber
Format: Article
Language:English
Subjects:
Animals
Bone Substitutes - pharmacology
Ceramics
Lumbar Vertebrae
Male
Medicine
Medicine & Public Health
Nanotubes, Carbon
Original Article
Orthopedics
Rats
Rats, Sprague-Dawley
Spinal Fusion - methods
X-Ray Microtomography
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Summary:Purpose The aim of the present study was to evaluate the effectiveness of carbon nanotubes (CNTs)/ HA–tricalcium phosphate (TCP) composite in a posterolateral spinal fusion model. Methods At first, CNTs and CNTs/HA–TCP composites were prepared. Twenty adult male Sprague Dawley rats were randomized into four groups with five rats in each group. Decortication was carried out in standard manner in all animals. Group 1 (only decortication), group 2 (CNTs), group 3 (HA–TCP) and group 4 (CNTs/HA–TCP) were formed. Eight weeks later, all animals were killed and obtained fusion segments were evaluated by manual palpation, histomorphometry and micro-computed tomography (mCT). Results In all evaluations, highest fusion values were obtained in Group 4. In mCT investigations, bone volume/ tissue volume (BV/TV) ratio was found to be significantly higher in composite group (group 4) only compared to ceramic group (group 3) ( p  
ISSN:2212-134X
2212-1358
DOI:10.1007/s43390-023-00659-0