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The combined use of carbon nanotubes with synthetic ceramics enhances posterolateral fusion: an experimental study in a rat spinal fusion model
Purpose The aim of the present study was to evaluate the effectiveness of carbon nanotubes (CNTs)/ HA–tricalcium phosphate (TCP) composite in a posterolateral spinal fusion model. Methods At first, CNTs and CNTs/HA–TCP composites were prepared. Twenty adult male Sprague Dawley rats were randomized i...
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| Published in: | Spine deformity 2023-07, Vol.11 (4), p.805-814 |
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| creator | Daldal, Ismail Senkoylu, Alpaslan Degim, Ismail Tuncer Ilbasmıs Tamer, Sibel Omeroglu, Suna Akarca Dizakar, Saadet Ozen Celik, Hakan Hamdi Uzuner, Muhammet Bora Kurtoglu, Alper Yapar, Dilek Yapar, Aliekber |
| description | Purpose
The aim of the present study was to evaluate the effectiveness of carbon nanotubes (CNTs)/ HA–tricalcium phosphate (TCP) composite in a posterolateral spinal fusion model.
Methods
At first, CNTs and CNTs/HA–TCP composites were prepared. Twenty adult male Sprague Dawley rats were randomized into four groups with five rats in each group. Decortication was carried out in standard manner in all animals. Group 1 (only decortication), group 2 (CNTs), group 3 (HA–TCP) and group 4 (CNTs/HA–TCP) were formed. Eight weeks later, all animals were killed and obtained fusion segments were evaluated by manual palpation, histomorphometry and micro-computed tomography (mCT).
Results
In all evaluations, highest fusion values were obtained in Group 4. In mCT investigations, bone volume/ tissue volume (BV/TV) ratio was found to be significantly higher in composite group (group 4) only compared to ceramic group (group 3) (
p
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| doi_str_mv | 10.1007/s43390-023-00659-0 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2774496166</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2774496166</sourcerecordid><originalsourceid>FETCH-LOGICAL-c298t-2496c4cc18f26810a9a0a21a68f782d093750e464ba3336d90a1e978a78af89c3</originalsourceid><addsrcrecordid>eNp9kctu1TAQhiMEolXpC7BAXrIJ-BbHZocqblIlNkViZ02cCSdVYgePIzhPwStjOOUssSzbmvnmt2b-pnku-CvBef-atFKOt1yqlnPTuZY_ai6lFLIVqrOPz2_99aK5JrrndVmrhe2eNhfK9B3vtLlsft0dkIW0DnPEke2ELE0sQB5SZBFiKvuAxH7M5cDoGMsByxxYwAzrHIhhPEAMFdgSFcxpgXrCwqad5hTfMIgMf26Y5xVjqXEq-3hkc2TAMhRG2xzPNFvTiMuz5skEC-H1w33VfHn_7u7mY3v7-cOnm7e3bZDOllZqZ4IOQdhJGis4OOAgBRg79VaO3KnaIGqjB1BKmdFxEOh6C3VP1gV11bw86W45fd-Ril9nCrgsEDHt5GXf6_qHMKai8oSGnIgyTn6rDUE-esH9Hy_8yQtfvfB_vfC8Fr140N-HFcdzyb_JV0CdAKqp-A2zv097ruOg_8n-BuZjlrY</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2774496166</pqid></control><display><type>article</type><title>The combined use of carbon nanotubes with synthetic ceramics enhances posterolateral fusion: an experimental study in a rat spinal fusion model</title><source>Springer Nature</source><creator>Daldal, Ismail ; Senkoylu, Alpaslan ; Degim, Ismail Tuncer ; Ilbasmıs Tamer, Sibel ; Omeroglu, Suna ; Akarca Dizakar, Saadet Ozen ; Celik, Hakan Hamdi ; Uzuner, Muhammet Bora ; Kurtoglu, Alper ; Yapar, Dilek ; Yapar, Aliekber</creator><creatorcontrib>Daldal, Ismail ; Senkoylu, Alpaslan ; Degim, Ismail Tuncer ; Ilbasmıs Tamer, Sibel ; Omeroglu, Suna ; Akarca Dizakar, Saadet Ozen ; Celik, Hakan Hamdi ; Uzuner, Muhammet Bora ; Kurtoglu, Alper ; Yapar, Dilek ; Yapar, Aliekber</creatorcontrib><description>Purpose
The aim of the present study was to evaluate the effectiveness of carbon nanotubes (CNTs)/ HA–tricalcium phosphate (TCP) composite in a posterolateral spinal fusion model.
Methods
At first, CNTs and CNTs/HA–TCP composites were prepared. Twenty adult male Sprague Dawley rats were randomized into four groups with five rats in each group. Decortication was carried out in standard manner in all animals. Group 1 (only decortication), group 2 (CNTs), group 3 (HA–TCP) and group 4 (CNTs/HA–TCP) were formed. Eight weeks later, all animals were killed and obtained fusion segments were evaluated by manual palpation, histomorphometry and micro-computed tomography (mCT).
Results
In all evaluations, highest fusion values were obtained in Group 4. In mCT investigations, bone volume/ tissue volume (BV/TV) ratio was found to be significantly higher in composite group (group 4) only compared to ceramic group (group 3) (
p
< 0.001). Although in Group 2, in which only CNTs were used, the ratio was found to be statistically significantly higher than group 1(
p
< 0.001), the difference was not considered as significant in terms of fusion and in addition in group 2, CNTs were completely surrounded by fibrous tissue, i.e., no bone formation was observed.
Conclusions
The CNTs/HA–TCP composite is a promising synthetic bone graft substitute for spinal fusion. Although CNTs are inadequate in producing spinal fusion when they are used alone, due to their high biocompatibility due to their high biocompatibility, and multiple effect on bone regeneration, they seem to increase fusion rates significantly when they are used in combination with ceramic-based synthetic grafts.</description><identifier>ISSN: 2212-134X</identifier><identifier>EISSN: 2212-1358</identifier><identifier>DOI: 10.1007/s43390-023-00659-0</identifier><identifier>PMID: 36750546</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Animals ; Bone Substitutes - pharmacology ; Ceramics ; Lumbar Vertebrae ; Male ; Medicine ; Medicine & Public Health ; Nanotubes, Carbon ; Original Article ; Orthopedics ; Rats ; Rats, Sprague-Dawley ; Spinal Fusion - methods ; X-Ray Microtomography</subject><ispartof>Spine deformity, 2023-07, Vol.11 (4), p.805-814</ispartof><rights>The Author(s), under exclusive licence to Scoliosis Research Society 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2023. The Author(s), under exclusive licence to Scoliosis Research Society.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c298t-2496c4cc18f26810a9a0a21a68f782d093750e464ba3336d90a1e978a78af89c3</cites><orcidid>0000-0001-6870-5515 ; 0000-0002-9918-4254 ; 0000-0002-9329-4698 ; 0000-0003-2227-2173 ; 0000-0003-0361-7105 ; 0000-0002-4358-6510 ; 0000-0001-6557-3086 ; 0000-0002-2149-0067 ; 0000-0001-7656-1152 ; 0000-0003-1124-4409 ; 0000-0001-9890-1330</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36750546$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Daldal, Ismail</creatorcontrib><creatorcontrib>Senkoylu, Alpaslan</creatorcontrib><creatorcontrib>Degim, Ismail Tuncer</creatorcontrib><creatorcontrib>Ilbasmıs Tamer, Sibel</creatorcontrib><creatorcontrib>Omeroglu, Suna</creatorcontrib><creatorcontrib>Akarca Dizakar, Saadet Ozen</creatorcontrib><creatorcontrib>Celik, Hakan Hamdi</creatorcontrib><creatorcontrib>Uzuner, Muhammet Bora</creatorcontrib><creatorcontrib>Kurtoglu, Alper</creatorcontrib><creatorcontrib>Yapar, Dilek</creatorcontrib><creatorcontrib>Yapar, Aliekber</creatorcontrib><title>The combined use of carbon nanotubes with synthetic ceramics enhances posterolateral fusion: an experimental study in a rat spinal fusion model</title><title>Spine deformity</title><addtitle>Spine Deform</addtitle><addtitle>Spine Deform</addtitle><description>Purpose
The aim of the present study was to evaluate the effectiveness of carbon nanotubes (CNTs)/ HA–tricalcium phosphate (TCP) composite in a posterolateral spinal fusion model.
Methods
At first, CNTs and CNTs/HA–TCP composites were prepared. Twenty adult male Sprague Dawley rats were randomized into four groups with five rats in each group. Decortication was carried out in standard manner in all animals. Group 1 (only decortication), group 2 (CNTs), group 3 (HA–TCP) and group 4 (CNTs/HA–TCP) were formed. Eight weeks later, all animals were killed and obtained fusion segments were evaluated by manual palpation, histomorphometry and micro-computed tomography (mCT).
Results
In all evaluations, highest fusion values were obtained in Group 4. In mCT investigations, bone volume/ tissue volume (BV/TV) ratio was found to be significantly higher in composite group (group 4) only compared to ceramic group (group 3) (
p
< 0.001). Although in Group 2, in which only CNTs were used, the ratio was found to be statistically significantly higher than group 1(
p
< 0.001), the difference was not considered as significant in terms of fusion and in addition in group 2, CNTs were completely surrounded by fibrous tissue, i.e., no bone formation was observed.
Conclusions
The CNTs/HA–TCP composite is a promising synthetic bone graft substitute for spinal fusion. Although CNTs are inadequate in producing spinal fusion when they are used alone, due to their high biocompatibility due to their high biocompatibility, and multiple effect on bone regeneration, they seem to increase fusion rates significantly when they are used in combination with ceramic-based synthetic grafts.</description><subject>Animals</subject><subject>Bone Substitutes - pharmacology</subject><subject>Ceramics</subject><subject>Lumbar Vertebrae</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Nanotubes, Carbon</subject><subject>Original Article</subject><subject>Orthopedics</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Spinal Fusion - methods</subject><subject>X-Ray Microtomography</subject><issn>2212-134X</issn><issn>2212-1358</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNp9kctu1TAQhiMEolXpC7BAXrIJ-BbHZocqblIlNkViZ02cCSdVYgePIzhPwStjOOUssSzbmvnmt2b-pnku-CvBef-atFKOt1yqlnPTuZY_ai6lFLIVqrOPz2_99aK5JrrndVmrhe2eNhfK9B3vtLlsft0dkIW0DnPEke2ELE0sQB5SZBFiKvuAxH7M5cDoGMsByxxYwAzrHIhhPEAMFdgSFcxpgXrCwqad5hTfMIgMf26Y5xVjqXEq-3hkc2TAMhRG2xzPNFvTiMuz5skEC-H1w33VfHn_7u7mY3v7-cOnm7e3bZDOllZqZ4IOQdhJGis4OOAgBRg79VaO3KnaIGqjB1BKmdFxEOh6C3VP1gV11bw86W45fd-Ril9nCrgsEDHt5GXf6_qHMKai8oSGnIgyTn6rDUE-esH9Hy_8yQtfvfB_vfC8Fr140N-HFcdzyb_JV0CdAKqp-A2zv097ruOg_8n-BuZjlrY</recordid><startdate>20230701</startdate><enddate>20230701</enddate><creator>Daldal, Ismail</creator><creator>Senkoylu, Alpaslan</creator><creator>Degim, Ismail Tuncer</creator><creator>Ilbasmıs Tamer, Sibel</creator><creator>Omeroglu, Suna</creator><creator>Akarca Dizakar, Saadet Ozen</creator><creator>Celik, Hakan Hamdi</creator><creator>Uzuner, Muhammet Bora</creator><creator>Kurtoglu, Alper</creator><creator>Yapar, Dilek</creator><creator>Yapar, Aliekber</creator><general>Springer International Publishing</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-6870-5515</orcidid><orcidid>https://orcid.org/0000-0002-9918-4254</orcidid><orcidid>https://orcid.org/0000-0002-9329-4698</orcidid><orcidid>https://orcid.org/0000-0003-2227-2173</orcidid><orcidid>https://orcid.org/0000-0003-0361-7105</orcidid><orcidid>https://orcid.org/0000-0002-4358-6510</orcidid><orcidid>https://orcid.org/0000-0001-6557-3086</orcidid><orcidid>https://orcid.org/0000-0002-2149-0067</orcidid><orcidid>https://orcid.org/0000-0001-7656-1152</orcidid><orcidid>https://orcid.org/0000-0003-1124-4409</orcidid><orcidid>https://orcid.org/0000-0001-9890-1330</orcidid></search><sort><creationdate>20230701</creationdate><title>The combined use of carbon nanotubes with synthetic ceramics enhances posterolateral fusion: an experimental study in a rat spinal fusion model</title><author>Daldal, Ismail ; Senkoylu, Alpaslan ; Degim, Ismail Tuncer ; Ilbasmıs Tamer, Sibel ; Omeroglu, Suna ; Akarca Dizakar, Saadet Ozen ; Celik, Hakan Hamdi ; Uzuner, Muhammet Bora ; Kurtoglu, Alper ; Yapar, Dilek ; Yapar, Aliekber</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c298t-2496c4cc18f26810a9a0a21a68f782d093750e464ba3336d90a1e978a78af89c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Animals</topic><topic>Bone Substitutes - pharmacology</topic><topic>Ceramics</topic><topic>Lumbar Vertebrae</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Nanotubes, Carbon</topic><topic>Original Article</topic><topic>Orthopedics</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Spinal Fusion - methods</topic><topic>X-Ray Microtomography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Daldal, Ismail</creatorcontrib><creatorcontrib>Senkoylu, Alpaslan</creatorcontrib><creatorcontrib>Degim, Ismail Tuncer</creatorcontrib><creatorcontrib>Ilbasmıs Tamer, Sibel</creatorcontrib><creatorcontrib>Omeroglu, Suna</creatorcontrib><creatorcontrib>Akarca Dizakar, Saadet Ozen</creatorcontrib><creatorcontrib>Celik, Hakan Hamdi</creatorcontrib><creatorcontrib>Uzuner, Muhammet Bora</creatorcontrib><creatorcontrib>Kurtoglu, Alper</creatorcontrib><creatorcontrib>Yapar, Dilek</creatorcontrib><creatorcontrib>Yapar, Aliekber</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Spine deformity</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Daldal, Ismail</au><au>Senkoylu, Alpaslan</au><au>Degim, Ismail Tuncer</au><au>Ilbasmıs Tamer, Sibel</au><au>Omeroglu, Suna</au><au>Akarca Dizakar, Saadet Ozen</au><au>Celik, Hakan Hamdi</au><au>Uzuner, Muhammet Bora</au><au>Kurtoglu, Alper</au><au>Yapar, Dilek</au><au>Yapar, Aliekber</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The combined use of carbon nanotubes with synthetic ceramics enhances posterolateral fusion: an experimental study in a rat spinal fusion model</atitle><jtitle>Spine deformity</jtitle><stitle>Spine Deform</stitle><addtitle>Spine Deform</addtitle><date>2023-07-01</date><risdate>2023</risdate><volume>11</volume><issue>4</issue><spage>805</spage><epage>814</epage><pages>805-814</pages><issn>2212-134X</issn><eissn>2212-1358</eissn><abstract>Purpose
The aim of the present study was to evaluate the effectiveness of carbon nanotubes (CNTs)/ HA–tricalcium phosphate (TCP) composite in a posterolateral spinal fusion model.
Methods
At first, CNTs and CNTs/HA–TCP composites were prepared. Twenty adult male Sprague Dawley rats were randomized into four groups with five rats in each group. Decortication was carried out in standard manner in all animals. Group 1 (only decortication), group 2 (CNTs), group 3 (HA–TCP) and group 4 (CNTs/HA–TCP) were formed. Eight weeks later, all animals were killed and obtained fusion segments were evaluated by manual palpation, histomorphometry and micro-computed tomography (mCT).
Results
In all evaluations, highest fusion values were obtained in Group 4. In mCT investigations, bone volume/ tissue volume (BV/TV) ratio was found to be significantly higher in composite group (group 4) only compared to ceramic group (group 3) (
p
< 0.001). Although in Group 2, in which only CNTs were used, the ratio was found to be statistically significantly higher than group 1(
p
< 0.001), the difference was not considered as significant in terms of fusion and in addition in group 2, CNTs were completely surrounded by fibrous tissue, i.e., no bone formation was observed.
Conclusions
The CNTs/HA–TCP composite is a promising synthetic bone graft substitute for spinal fusion. Although CNTs are inadequate in producing spinal fusion when they are used alone, due to their high biocompatibility due to their high biocompatibility, and multiple effect on bone regeneration, they seem to increase fusion rates significantly when they are used in combination with ceramic-based synthetic grafts.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>36750546</pmid><doi>10.1007/s43390-023-00659-0</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0001-6870-5515</orcidid><orcidid>https://orcid.org/0000-0002-9918-4254</orcidid><orcidid>https://orcid.org/0000-0002-9329-4698</orcidid><orcidid>https://orcid.org/0000-0003-2227-2173</orcidid><orcidid>https://orcid.org/0000-0003-0361-7105</orcidid><orcidid>https://orcid.org/0000-0002-4358-6510</orcidid><orcidid>https://orcid.org/0000-0001-6557-3086</orcidid><orcidid>https://orcid.org/0000-0002-2149-0067</orcidid><orcidid>https://orcid.org/0000-0001-7656-1152</orcidid><orcidid>https://orcid.org/0000-0003-1124-4409</orcidid><orcidid>https://orcid.org/0000-0001-9890-1330</orcidid></addata></record> |
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| ispartof | Spine deformity, 2023-07, Vol.11 (4), p.805-814 |
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| subjects | Animals Bone Substitutes - pharmacology Ceramics Lumbar Vertebrae Male Medicine Medicine & Public Health Nanotubes, Carbon Original Article Orthopedics Rats Rats, Sprague-Dawley Spinal Fusion - methods X-Ray Microtomography |
| title | The combined use of carbon nanotubes with synthetic ceramics enhances posterolateral fusion: an experimental study in a rat spinal fusion model |
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