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Effects of oral HPΒCD-angiotensin-(1-7) supplementation on recreational mountain bike athletes: a crossover study

Supplementation with Angiotensin-(1-7) [(Ang-1-7)] has received considerable attention due to its possible ergogenic effects on physical performance. The effects of a single dose of Ang-(1-7) on the performance of mountain bike (MTB) athletes during progressive load tests performed until the onset o...

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Published in:The Physician and sportsmedicine 2024-02, Vol.ahead-of-print (ahead-of-print), p.1-12
Main Authors: Silva de Moura, Samara, de Assis Dias Martins-Júnior, Francisco, Cruz de Oliveira, Emerson, Coelho, Daniel Barbosa, Boari, Daniel, Lima-Silva, Adriano Eduardo, Motta-Santos, Daisy, Augusto Souza Dos Santos, Robson, Becker, Lenice Kappes
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container_title The Physician and sportsmedicine
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creator Silva de Moura, Samara
de Assis Dias Martins-Júnior, Francisco
Cruz de Oliveira, Emerson
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Motta-Santos, Daisy
Augusto Souza Dos Santos, Robson
Becker, Lenice Kappes
description Supplementation with Angiotensin-(1-7) [(Ang-1-7)] has received considerable attention due to its possible ergogenic effects on physical performance. The effects of a single dose of Ang-(1-7) on the performance of mountain bike (MTB) athletes during progressive load tests performed until the onset of voluntary fatigue have previously been demonstrated. This study tested the effects of Ang-(1-7) in two different exercise protocols with different metabolic demands: aerobic (time trial) and anaerobic (repeated sprint). Twenty one male recreational athletes were given capsules containing an oral formulation of HPβCD-Ang-(1-7) (0.8 mg) and HPβCD-placebo (only HPβCD) over a 7-day interval; a double-blind randomized crossover design was used. Physical performance was examined using two protocols: a 20-km cycling time trial or 4 × 30-s repeated all-out sprints on a leg cycle ergometer. Data were collected before and after physical tests to assess fatigue parameters, and included lactate levels, and muscle activation during the sprint protocol as evaluated by electromyography (EMG); cardiovascular parameters: diastolic and systolic blood pressure and heart rate; and performance parameters, time to complete (time trial), maximum power and mean power (repeated sprint). Supplementation with an oral formulation of HPβCD-Ang-(1-7) reduced basal plasma lactate levels and promoted the maintenance of plasma glucose levels after repeated sprints. Supplementation with HPβCD-Ang-(1-7) also increased baseline plasma nitrite levels and reduced resting diastolic blood pressure in a time trial protocol. HPβCD-Ang-(1-7) had no effect on the time trial or repeat sprint performance, or on the EMG recordings of the vastus lateralis and vastus medialis. Supplementation with HPβCD-Ang-(1-7) did not improve physical performance in time trial or in repeated sprints; however, it promoted the maintenance of plasma glucose and lactate levels after the sprint protocol and at rest, respectively. In addition, HPβCD-Ang-(1-7) also increased resting plasma nitrite levels and reduced diastolic blood pressure in the time trial protocol. RBR-2nbmpbc, registered January 6th, 2023. The study was prospectively registered.
doi_str_mv 10.1080/00913847.2023.2175587
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subjects Angiotensin-(1-7)
exercise
mountain bike
nutrition
time trial 20 km and repeat sprint
title Effects of oral HPΒCD-angiotensin-(1-7) supplementation on recreational mountain bike athletes: a crossover study
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