Resveratrol regulates inflammation and improves oxidative stress via Nrf2 signaling pathway: Therapeutic and biotechnological prospects

Usually, in aerobic metabolism, natural materials including nucleic acids, proteins, and lipids can experience auxiliary injury by oxidative responses. This damage produced by reactive oxygen/nitrogen species has been identified as “oxidative stress.” As a natural polyphenol got from red wine and pe...

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Bibliographic Details
Published in:Phytotherapy research 2023-04, Vol.37 (4), p.1590-1605
Main Authors: Shahcheraghi, Seyed Hossein, Salemi, Fateme, Small, Shlomo, Syed, Suliman, Salari, Farzam, Alam, Waqas, Cheang, Wai San, Saso, Luciano, Khan, Haroon
Format: Article
Language:English
Subjects:
Aging (natural)
Biosynthesis
biotechnological prospects
Biotransformation
Carbohydrates
Humans
Inflammation
Inflammation - drug therapy
Lipid metabolism
Lipids
NF-E2-Related Factor 2 - metabolism
Nrf2
Nucleic acids
Oxidative Stress
Oxygen
Reactive Nitrogen Species
Reactive Oxygen Species - metabolism
Resveratrol
Resveratrol - therapeutic use
Signal Transduction
Signaling
therapeutic status
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Summary:Usually, in aerobic metabolism, natural materials including nucleic acids, proteins, and lipids can experience auxiliary injury by oxidative responses. This damage produced by reactive oxygen/nitrogen species has been identified as “oxidative stress.” As a natural polyphenol got from red wine and peanuts, resveratrol is one of the most eminent anti‐aging mixtures. Based on many studies', resveratrol hinders destructive effects of inflammatory causes and reactive oxygen radicals in several tissues. The nuclear erythroid 2‐related factor 2 is a factor related to transcription with anti‐inflammatory, antioxidant possessions which is complicated by enzyme biotransformation and biosynthesis of lipids and carbohydrates. This review provides current understanding and information about the character of resveratrol against oxidative stress and regulation of inflammation via Nrf2 signaling pathway.
ISSN:0951-418X
1099-1573
DOI:10.1002/ptr.7754