Antibacterial composite: polymeric mesoporous silica nanoparticles and combination of imipenem/meropenem

Using nanomaterials is a novel strategy to eliminate drug resistance against bacteria. Nanoparticles with metal sites show antimicrobial activities that counteract or obstruct antibiotic-resistant mechanisms expressed by the pathogens. Here, a nanocomposite based on mesoporous silica nanoparticles w...

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Bibliographic Details
Published in:Journal of materials chemistry. B, Materials for biology and medicine Materials for biology and medicine, 2023-03, Vol.11 (9), p.1971-1977
Main Authors: Tabriz, Pegah Tabatabaei, Maghsodi, Parisa Haji, Afarin, Alireza Jahan, Heydari, Hengameh, Amiry, Forough, Sazegar, Mohammad Reza
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - chemistry
Antibiotic resistance
Antibiotics
Antiinfectives and antibacterials
Bacteria
Drug resistance
E coli
Escherichia coli
Humans
Imipenem
Klebsiella
Klebsiella pneumoniae
Meropenem
Microorganisms
Nanocomposites
Nanomaterials
Nanoparticles
Nanotechnology
Penetration resistance
Plasmids
Reactive oxygen species
Silica
Silicon dioxide
Silicon Dioxide - chemistry
Silver
Staphylococcus aureus
Synthesis
β Lactamase
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Summary:Using nanomaterials is a novel strategy to eliminate drug resistance against bacteria. Nanoparticles with metal sites show antimicrobial activities that counteract or obstruct antibiotic-resistant mechanisms expressed by the pathogens. Here, a nanocomposite based on mesoporous silica nanoparticles with active sites of silver, and a combination of imipenem and meropenem as antibiotic drugs, was synthesized and characterized using different physicochemical methods. The antibacterial assessments exhibited sensitivity by Staphylococcus aureus ( S. aureus ), Klebsiella pneumoniae ( K. pneumoniae ) and Escherichia coli ( E. coli ) toward the synthesized composite, which showed a suitable safety profile in human cells. This composite has an excellent synergic mechanism based on reactive oxygen species (ROS) to kill bacteria due to penetrating the microbial membrane. In addition, this composite is resistant to hydrolysis by plasmids and chromosomally mediated β-lactamases. This nanocomposite showed extraordinary antiseptic power against Gram-positive and Gram-negative microbes. High-efficiency antibacterial activity of meropenem-imipenem in a new nanocomposite framework including silver-modified mesoporous silica nanoparticles and chitosan.
ISSN:2050-750X
2050-7518
DOI:10.1039/d2tb02442j