The Role of Non-coding RNAs in Methamphetamine-Induced Neurotoxicity

Methamphetamine (METH) is an amphetamine-type stimulant that is highly toxic to the central nervous system (CNS). Repeated intake of METH can lead to addiction, which has become a globalized problem, resulting in multiple public health and safety problems. Recently, the non-coding RNA (ncRNA) has be...

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Bibliographic Details
Published in:Cellular and molecular neurobiology 2023-08, Vol.43 (6), p.2415-2436
Main Authors: Xu, Luyao, Li, Lingyue, Chen, Qianling, Huang, Yuebing, Chen, Xuebing, Qiao, Dongfang
Format: Article
Language:English
Subjects:
Addictions
Amphetamine
Amphetamines
Behavior, Addictive
Biomedical and Life Sciences
Biomedicine
Blood-brain barrier
Cell Biology
Central nervous system
Circular RNA
Cognitive ability
Humans
Mental disorders
Methamphetamine
Methamphetamine - toxicity
MicroRNAs
MicroRNAs - metabolism
miRNA
Neurobiology
Neurosciences
Neurotoxicity
Neurotoxicity Syndromes - genetics
Neurotransmission
Non-coding RNA
Public health
Review Paper
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Summary:Methamphetamine (METH) is an amphetamine-type stimulant that is highly toxic to the central nervous system (CNS). Repeated intake of METH can lead to addiction, which has become a globalized problem, resulting in multiple public health and safety problems. Recently, the non-coding RNA (ncRNA) has been certified to play an essential role in METH addiction through various mechanisms. Herein, we mainly focused on three kinds of ncRNAs including long non-coding RNAs (lncRNAs), microRNAs (miRNAs), and circular RNAs (circRNAs), which are involved in neurotoxicity effects such as cognitive impairment, behavioral abnormalities, and psychiatric disorders due to METH abuse. In addition, differential expression (DE) ncRNAs also suggest that specific responses and sensitivity to METH neurotoxicity exist in different brain regions and cells. We summarized the relationships between the ncRNAs and METH-induced neurotoxicity and psychiatric disturbances, respectively, hoping to provide new perspectives and strategies for the prevention and treatment of METH abuse. Graphical Abstract Schematic diagram of the non-coding RNAs (ncRNAs) was involved in methamphetamine (METH)-induced neurotoxicity. The ncRNAs were involved in METH-induced blood–brain barrier disruption, neuronal, astrocyte, and microglial damage, and synaptic neurotransmission impairment. The study of ncRNAs is a hot spot in the future to further understand the neurotoxicity of METH and provide more favorable scientific support for clinical diagnosis and innovation of related treatments.
ISSN:0272-4340
1573-6830
DOI:10.1007/s10571-023-01323-x