A prolonged fast improves overnight substrate oxidation without modulating hepatic glycogen in adults with and without nonalcoholic fatty liver: A randomized crossover trial

Objective Increasing overnight fasting time seems a promising strategy to improve metabolic health in individuals with nonalcoholic fatty liver (NAFL). Mechanisms underlying the beneficial effects of fasting may be related to larger fluctuations in hepatic glycogen and higher fat oxidation. This stu...

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Published in:Obesity (Silver Spring, Md.) Md.), 2023-03, Vol.31 (3), p.757-767
Main Authors: Roumans, Kay H. M., Veelen, Anna, Andriessen, Charlotte, Mevenkamp, Julian, Kornips, Esther, Veeraiah, Pandichelvam, Havekes, Bas, Peters, Harry P. F., Lindeboom, Lucas, Schrauwen, Patrick, Schrauwen‐Hinderling, Vera B.
Format: Article
Language:English
Subjects:
Adult
Body mass index
Carbohydrates
Carbohydrates - pharmacology
Cross-Over Studies
Diabetes
Energy
Fasting
Food
Humans
Insulin
Intervention
Liver
Liver - metabolism
Liver Glycogen - metabolism
Liver Glycogen - pharmacology
Metabolism
Non-alcoholic Fatty Liver Disease - metabolism
Overweight
Oxidation
Oxidation-Reduction
Spectrum analysis
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Summary:Objective Increasing overnight fasting time seems a promising strategy to improve metabolic health in individuals with nonalcoholic fatty liver (NAFL). Mechanisms underlying the beneficial effects of fasting may be related to larger fluctuations in hepatic glycogen and higher fat oxidation. This study investigated whether prolonging an overnight fast depletes hepatic glycogen stores and improves substrate metabolism in individuals with NAFL and healthy lean individuals. Methods Eleven individuals with NAFL and ten control individuals participated in this randomized crossover trial. After a 9.5‐hour or 16‐hour fast, hepatic glycogen was measured by using carbon‐13 magnetic resonance spectroscopy, and a meal test was performed. Nocturnal substrate oxidation was measured with indirect calorimetry. Results Extending fasting time led to lower nocturnal carbohydrate oxidation and higher fat oxidation in both groups (intervention × time, p 
ISSN:1930-7381
1930-739X
DOI:10.1002/oby.23676