An oracle predicts regulators of cell identity

A computational tool called CellOracle can predict how networks of genes interact to program cell identity during embryonic development. The tool should help to hone efforts to understand how development is regulated. A computational tool to identify developmental regulators.

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Bibliographic Details
Published in:Nature (London) 2023-02, Vol.614 (7949), p.630-632
Main Author: Farrell, Jeffrey A.
Format: Article
Language:English
Subjects:
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631/136
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Amino acids
Blood
Computational Biology
Computer applications
CRISPR
Depletion
Embryos
Erythrocytes
Genes
Genetic engineering
Genetic modification
Humanities and Social Sciences
Hypotheses
multidisciplinary
Mutation
News And Views
Perturbation
Preprints
PU.1 protein
Science
Systems Biology
Transcription factors
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Description
Summary:A computational tool called CellOracle can predict how networks of genes interact to program cell identity during embryonic development. The tool should help to hone efforts to understand how development is regulated. A computational tool to identify developmental regulators.
ISSN:0028-0836
1476-4687
DOI:10.1038/d41586-023-00251-6