Incretins play an important role in FFA4/GPR120 regulation of glucose metabolism by GW-9508

To assess the role of GPR120 in glucose metabolism and incretin regulation from enteroendocrine L- and K-cells with determination of the cellular localisation of GPR120 in intestinal tissue and clonal Glucagon-Like Peptide-1 (GLP-1)/Gastric Inhibitory Polypeptide (GIP) cell lines. Anti-hyperglycaemi...

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Bibliographic Details
Published in:Life sciences (1973) 2023-04, Vol.318, p.121475-121475, Article 121475
Main Authors: McKillop, Aine M., Miskelly, Michael G., Moran, Brian M., Flatt, Peter R.
Format: Article
Language:English
Subjects:
Animals
Blood Glucose - metabolism
Diabetes
Diabetes Mellitus, Experimental - drug therapy
G-protein coupled receptor
Gastric Inhibitory Polypeptide
GIP
GLP-1
Glucagon-Like Peptide 1 - metabolism
Glucose
GW-9508
Incretins - therapeutic use
Insulin - metabolism
Insulins - therapeutic use
Mice
Mice, Knockout
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Summary:To assess the role of GPR120 in glucose metabolism and incretin regulation from enteroendocrine L- and K-cells with determination of the cellular localisation of GPR120 in intestinal tissue and clonal Glucagon-Like Peptide-1 (GLP-1)/Gastric Inhibitory Polypeptide (GIP) cell lines. Anti-hyperglycaemic, insulinotropic and incretin secreting properties of the GPR120 agonist, GW-9508 were explored in combination with oral and intraperitoneal glucose tolerance tests (GTT) in lean, diabetic and incretin receptor knockout mice. Cellular localisation of GPR120 was assessed by double immunofluorescence. Compared to intraperitoneal injection, oral administration of GW-9508 (0.1 μmol/kg body weight) together with glucose reduced the glycaemic excursion by 22–31 % (p 
ISSN:0024-3205
1879-0631
DOI:10.1016/j.lfs.2023.121475