Outcomes of adult patients with early T-cell precursor (ETP) acute lymphoblastic leukemia/lymphoma (ALL) and non-ETP T-ALL

Early T-cell precursor (ETP) acute lymphoblastic leukemia/lymphoma (ALL) is generally considered to be a high-risk subtype. We retrospectively analyzed the clinical outcomes of adult patients diagnosed with ETP-ALL or other T-cell ALL (non-ETP T-ALL). The subjects were 82 patients (ETP-ALL: n  = 18,...

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Bibliographic Details
Published in:International journal of hematology 2023-05, Vol.117 (5), p.738-747
Main Authors: Onishi, Yasushi, Furukawa, Eijiro, Kamata, Mayumi, Fukatsu, Masahiko, Kameoka, Yoshihiro, Hatta, Shunsuke, Hamada, Hiroyuki, Oyake, Tatsuo, Kai, Tatsuyuki, Sukegawa, Masumi, Nakajima, Shinji, Yanagiya, Ryo, Yamaguchi, Kohei, Takahashi, Taro, Harazaki, Yoriko, Izumi, Toru, Murai, Kazunori, Ito, Shigeki, Ikezoe, Takayuki, Ishizawa, Kenichi, Takahashi, Naoto, Harigae, Hideo
Format: Article
Language:English
Subjects:
Acute lymphoblastic leukemia
Chemotherapy
Hematology
Humans
Induction therapy
Leukemia
Lymphocytes T
Lymphoma
Male
Medical prognosis
Medicine
Medicine & Public Health
Multivariate analysis
Oncology
Original Article
Phenotypes
Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy
Precursor Cells, T-Lymphoid
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - diagnosis
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - drug therapy
Precursors
Prognosis
Remission
Remission (Medicine)
Retrospective Studies
Survival
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Summary:Early T-cell precursor (ETP) acute lymphoblastic leukemia/lymphoma (ALL) is generally considered to be a high-risk subtype. We retrospectively analyzed the clinical outcomes of adult patients diagnosed with ETP-ALL or other T-cell ALL (non-ETP T-ALL). The subjects were 82 patients (ETP-ALL: n  = 18, non-ETP T-ALL: n  = 64) for whom relevant immunophenotype data needed for classification were available. ETP-ALL patients were older (median age, 50.5 vs. 33.5 years, P  = 0.042) and had less mediastinal involvement (27.8 vs. 73.4%, P  
ISSN:0925-5710
1865-3774
DOI:10.1007/s12185-023-03546-6