Structure and process relationship of electrospun bioabsorbable nanofiber membranes

• Published in: Polymer (Guilford) 2002-07, Vol.43 (16), p.4403-4412
• Main Authors: Zong, Xinhua, Kim, Kwangsok, Fang, Dufei, Ran, Shaofeng, Hsiao, Benjamin S, Chu, Benjamin
• Format: Article
• Language: English
• Subjects: Applied sciences; Biodegradable nanofiber; Biological and medical sciences; Electrospinning; Exact sciences and technology; Exchange resins and membranes; Forms of application and semi-finished materials; General pharmacology; Medical sciences; Pharmaceutical technology. Pharmaceutical industry; Pharmacology. Drug treatments; Poly(lactic acid); Polymer industry, paints, wood; Technology of polymers
• ISSN: 0032-3861; 1873-2291
• DOI: 10.1016/S0032-3861(02)00275-6

An electrospinning method was used to fabricate bioabsorbable amorphous poly( d, l-lactic acid) (PDLA) and semi-crystalline poly( l-lactic acid) (PLLA) nanofiber non-woven membranes for biomedical applications. The structure and morphology of electrospun membranes were investigated by scanning electron microscopy (SEM), differential scanning calorimetry (DSC), and synchrotron wide-angle X-ray diffraction/small angle X-ray scattering. SEM images showed that the fiber diameter and the nanostructured morphology depended on processing parameters such as solution viscosity (e.g. concentration and polymer molecular weight), applied electric field strength, solution feeding rate and ionic salt addition. The combination of different materials and processing parameters could be used to fabricate bead-free nanofiber non-woven membranes. Concentration and salt addition were found to have relatively larger effects on the fiber diameter than the other parameters. DSC and X-ray results indicated that the electrospun PLLA nanofibers were completely non-crystalline but had highly oriented chains and a lower glass transition temperature than the cast film.