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Brain regional homogeneity and its association with age and intelligence in typically developing youth

Accelerated synaptic pruning and weakening of short-range functional connectivity are characteristic of adolescent brain development. Based on these structural microscopic and system-level functional changes, it was hypothesized that regional homogeneity (ReHo) may decrease with age in the developin...

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Bibliographic Details
Published in:Asian journal of psychiatry 2023-04, Vol.82, p.103497-103497, Article 103497
Main Author: Hong, Soon-Beom
Format: Article
Language:English
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Summary:Accelerated synaptic pruning and weakening of short-range functional connectivity are characteristic of adolescent brain development. Based on these structural microscopic and system-level functional changes, it was hypothesized that regional homogeneity (ReHo) may decrease with age in the developing brain, and a differential association between ReHo and cognitive performance was expected to depend on age. ReHo maps of typically developing participants were provided by the Attention-Deficit/Hyperactivity Disorder (ADHD)-200 Preprocessed repository. Intelligence quotient was evaluated using the Wechsler Intelligence Scale for Chinese Children-Revised and Wechsler Abbreviated Scale of Intelligence at Peking University and New York University, respectively. Correlations between ReHo and age were examined, along with the interaction effects of ReHo and age on intelligence quotient (IQ), in 121 typically developing youth aged 8–14 years. Of the 400 ROIs tested, ReHo in 105 brain regions was significantly correlated with age (p 
ISSN:1876-2018
1876-2026
DOI:10.1016/j.ajp.2023.103497