Effect of topical oxytocin gel on vaginal mucosa in postmenopausal Egyptian women: a clinical randomized trial

Vaginal atrophy is common after menopause and is often linked to sexual dysfunction, particularly dyspareunia. The study aimed to investigate the effect of intravaginally applied oxytocin on expressions of vaginal atrophy. Fifty postmenopausal women aged 47 to 66 years with vaginal atrophy participa...

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Bibliographic Details
Published in:Journal of sexual medicine 2023-02, Vol.20 (2), p.177-183
Main Authors: Moussa, Asem, Moberg, Kerstin Uvnäs, Elgrahy, Ismael, Elsayied, Mohammad, Abdel-Rasheed, Mazen, Farouk, Mohamed, Saad, Hany, Meshaal, Hadeer
Format: Article
Language:English
Subjects:
Administration, Intravaginal
Atrophy - drug therapy
Atrophy - pathology
Double-Blind Method
Egypt
Female
Humans
Mucous Membrane
Oxytocin - pharmacology
Oxytocin - therapeutic use
Postmenopause
Treatment Outcome
Vagina - pathology
Vaginal Diseases - drug therapy
Vaginal Diseases - pathology
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Summary:Vaginal atrophy is common after menopause and is often linked to sexual dysfunction, particularly dyspareunia. The study aimed to investigate the effect of intravaginally applied oxytocin on expressions of vaginal atrophy. Fifty postmenopausal women aged 47 to 66 years with vaginal atrophy participated in this double-blinded placebo-controlled study. The women were randomized to intravaginal treatment with either gel with 600 IU/mL of oxytocin (oxytocin group) or gel alone (control group) once daily for 2 weeks. The gel consisted of hypromellose, pH 3.8 (Vagovital). The color of the vaginal mucosa, the vaginal pH, and the cytology of vaginal epithelial cells were investigated before and after treatment. The color of the vaginal mucosa shifted from pale to red in all 25 patients treated with oxytocin but only in 4 patients in the control group (P 
ISSN:1743-6095
1743-6109
DOI:10.1093/jsxmed/qdac021