Incidence and presentation of new-onset type 1 diabetes in children and adolescents from Germany during the COVID-19 pandemic 2020 and 2021: Current data from the DPV Registry

•Comparison of incidence/frequency 2020/2021 with long-term trends (2011–2019)•The observed diabetes incidence in 2020/2021 was 13%/20% higher than predicted.•The prevalence of autoantibody-negative diabetes was not higher than predicted.•Ketoacidosis incidence in 2020/2021 was 34%/37% higher than e...

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Published in:Diabetes research and clinical practice 2023-03, Vol.197, p.110559-110559, Article 110559
Main Authors: Baechle, C., Eckert, A., Kamrath, C., Neu, A., Manuwald, U., Thiele-Schmitz, S., Weidler, O., Knauer-Fischer, S., Rosenbauer, J., Holl, R.W.
Format: Article
Language:English
Subjects:
Adolescent
Adolescents
Child
COVID-19 - complications
COVID-19 - epidemiology
Diabetes Mellitus, Type 1 - complications
Diabetes Mellitus, Type 1 - epidemiology
Diabetic ketoacidosis
Diabetic Ketoacidosis - etiology
Germany
Germany - epidemiology
Humans
Incidence
Pandemics
Prospective Studies
Registries
Registry
Type 1 diabetes
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Summary:•Comparison of incidence/frequency 2020/2021 with long-term trends (2011–2019)•The observed diabetes incidence in 2020/2021 was 13%/20% higher than predicted.•The prevalence of autoantibody-negative diabetes was not higher than predicted.•Ketoacidosis incidence in 2020/2021 was 34%/37% higher than expected.•Seasonal patterns have substantially changed during the COVID-19 pandemic. To determine whether the incidence of type 1 diabetes mellitus (T1D), autoantibody-negative diabetes, and diabetic ketoacidosis (DKA) at diabetes onset in 2020 and 2021 changed when compared to long-standing trends. Our study is based on diabetes manifestation data of the 0.5–
ISSN:0168-8227
1872-8227
DOI:10.1016/j.diabres.2023.110559