Newly evolved genes in the human lineage are functional

Genes restricted to a given species or lineage are mysterious. Many emerged de novo from ancestral noncoding genomic regions rather than from pre-existing genes. A new study by Vakirlis and colleagues shows that, in humans, many of these are associated with phenotypic effects, accelerating our under...

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Bibliographic Details
Published in:Trends in genetics 2023-04, Vol.39 (4), p.235-236
Main Authors: Papadopoulos, Chris, Albà, M. Mar
Format: Article
Language:English
Subjects:
Animals
CRISPR-Cas Systems
CRISPR-Cas9
de novo gene
Evolution, Molecular
Genome
Genomics
Hominidae
Humans
microprotein
ribosome profiling
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Description
Summary:Genes restricted to a given species or lineage are mysterious. Many emerged de novo from ancestral noncoding genomic regions rather than from pre-existing genes. A new study by Vakirlis and colleagues shows that, in humans, many of these are associated with phenotypic effects, accelerating our understanding of their functional importance.
ISSN:0168-9525
DOI:10.1016/j.tig.2023.02.001